Salanci B Volkan, Ergün E Lay
Nuclear Medicine Department, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Rev Esp Med Nucl. 2006 May-Jun;25(3):198-201. doi: 10.1157/13088418.
I-131 MIBG scintigraphy is routinely used in the diagnosis of neuroendocrine tumours with high specificity. The radiopharmaceutical is taken up via uptake mechanism and actively transported into storage vesicules. The organs with dense sympathetic innervation such as salivary glands, heart, lachrymal glands, spleen and rarely adrenal medulla are normally visualized with I-131 MIBG. Asymetrical salivary gland uptake is important in a patient with suspected neuroendocrine tumours. Absence of radioactivity may be a result of sympathic denervation or tumor. Bilateral radioactivity absence is observed usually due to drugs or radiopharmaceutical storage conditions. Detailed examination of cervical region is crucial for localisation of neuroendocrine tumours. Therefore, possible false positives should be kept in mind.
I-131间碘苄胍闪烁扫描术通常用于诊断具有高特异性的神经内分泌肿瘤。放射性药物通过摄取机制被摄取，并被主动转运到储存囊泡中。具有密集交感神经支配的器官，如唾液腺、心脏、泪腺、脾脏，很少还有肾上腺髓质，通常可通过I-131间碘苄胍显影。在疑似神经内分泌肿瘤的患者中，不对称的唾液腺摄取很重要。放射性缺失可能是交感神经去神经支配或肿瘤的结果。双侧放射性缺失通常是由于药物或放射性药物储存条件所致。对颈部区域进行详细检查对于神经内分泌肿瘤的定位至关重要。因此，应牢记可能出现的假阳性结果。
