Varela Aguilar J M, Medrano Ortega F J, Calderón Sandubete E
Servicio de Medicina Interna, Hospital Universitario Virgen del Rocío, Sevilla, España.
Rev Clin Esp. 2006 Jun;206(6):278-80. doi: 10.1157/13088588.
Pneumonia due to Pneumocystis is an important cause of morbidity-mortality among immunodepressed patients, above all with human immunodeficiency virus infection and finally in patients with transplants, oncology patients and those subjected to drug immunodepression. Its lack of capacity to grow in the usual culture mediums has hindered knowledge on many aspects of this infection (transmission, acquisition mode, infection sources). However, the incorporation of molecular biology tools in recent years has made it possible to go deeper into the understanding of the epidemiology, biology and characteristics of the infection by this pathogen. These advances have led to the modification of the taxonomic classification of this atypical fungus and change in the name of the Pneumocystis responsible for the infection in humans, which is now called Pneumocystis jirovecii. During this article, we will show some of the most recent advances in the knowledge of the human pneumocystosis.
肺孢子菌肺炎是免疫抑制患者发病和死亡的重要原因,尤其是在人类免疫缺陷病毒感染患者中,最终在移植患者、肿瘤患者以及接受药物免疫抑制的患者中。它在常用培养基中缺乏生长能力,这阻碍了对这种感染许多方面(传播、感染方式、感染源)的了解。然而,近年来分子生物学工具的应用使得深入了解这种病原体感染的流行病学、生物学和特征成为可能。这些进展导致了这种非典型真菌分类学分类的修改以及引起人类感染的肺孢子菌名称的改变,现在称为耶氏肺孢子菌。在本文中,我们将展示人类肺孢子菌病知识的一些最新进展。