Yu De-kuang, Yang Yi, Yin Bing-sheng, Li Ben-fu, Nong De-bin, Zhou Xiang
Cardiac Electricity Research Center, College of Basic Medicine, Southern Medical University, Guangzhou 510515, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2006 May;26(5):549-52.
Conventional medical experiments can hardly simulate cardiac excitation propagation and observe the evolvement of cardiac electrical activities firsthand as is possible with computer simulation. Based on the anatomic structure of the heart, simulation of cardiac electrical activity mainly consists of the emulation of the excitation process among the cardiac cells and calculation of the electrical activities of individual cardiac cells. In this study we establish a geometric ventricular structure model demonstrating the direction of the cardiac muscle fibers and the layers of the ventricular cells, and endow different action potential models to the ventricular cells of different layers, and observe the activation process of the ventricular parts in view of the three-dimensional anatomy. This method gives attention to both enough calculation amounts and efficiency, which achieves satisfactory simulation results of ventricular electrical activity based on the anatomic structure and cell electrophysiology through an improved algorithm on personal computer.
传统医学实验很难模拟心脏兴奋传播，也无法像计算机模拟那样直接观察心脏电活动的演变。基于心脏的解剖结构，心脏电活动模拟主要包括模拟心脏细胞间的兴奋过程以及计算单个心脏细胞的电活动。在本研究中，我们建立了一个几何心室结构模型，该模型展示了心肌纤维的方向和心室细胞的层次，并赋予不同层次的心室细胞不同的动作电位模型，然后从三维解剖学角度观察心室各部分的激活过程。这种方法兼顾了计算量和效率，通过在个人计算机上改进算法，基于解剖结构和细胞电生理学实现了令人满意的心室电活动模拟结果。
