健康印度成年人每日苯丙氨酸需求量。

The daily phenylalanine requirement of healthy Indian adults.

作者信息

Kurpad Anura V, Regan Meredith M, Raj Tony D S, Rao Vidya N, Gnanou Justin, Young Vernon R

机构信息

Institute of Population Health and Clinical Research, St John's National Academy of Health Sciences, Bangalore, India.

出版信息

Am J Clin Nutr. 2006 Jun;83(6):1331-6. doi: 10.1093/ajcn/83.6.1331.

DOI:10.1093/ajcn/83.6.1331

PMID:16762944

Abstract

BACKGROUND

The daily requirement for phenylalanine is not known with certainty. Earlier 24-h tracer studies have suggested that the requirement is between 30 and 40 mg . kg(-1) . d(-1).

OBJECTIVE

The objective was to assess the phenylalanine requirement in healthy well-nourished Indians with the use of 8 test phenylalanine intakes (19, 23, 27, 31, 35, 38, 43, and 47 mg . kg(-1) . d(-1)) and the 24-h indicator amino acid oxidation (24-h IAAO) and 24-h indicator amino acid balance (24-h IAAB) methods.

DESIGN

Thirty-two healthy, well-nourished Indian men were studied during each of 2 randomly assigned 6-d diet periods in which phenylalanine intakes of 19, 23, 27, 31, 35, 38, 43, and 47 mg . kg(-1) . d(-1) were supplied; the diet was devoid of tyrosine. A 24-h [13C]leucine tracer infusion was used to measure 24-h IAAO and 24-h IAAB on day 7. The breakpoint in the relation between these values and the phenylalanine intake was determined.

RESULTS

Two-phase linear regression of daily leucine oxidation and balance against phenylalanine intake estimated a breakpoint in the response curve at phenylalanine intakes of 37 and 38 mg . kg(-1) . d(-1) (95% CI for both: 31, >47 mg . kg(-1) . d(-1)), respectively.

CONCLUSION

On the basis of the 24-h IAAO and 24-h IAAB methods, a mean phenylalanine requirement of 38 mg . kg(-1) . d(-1) is proposed for healthy well-nourished Indian adults in the absence of tyrosine intake. This finding is similar to that in Western adults.

摘要

背景

苯丙氨酸的每日需求量尚不确定。早期的24小时示踪研究表明，需求量在30至40毫克·千克⁻¹·天⁻¹之间。

目的

目的是通过使用8种测试苯丙氨酸摄入量（19、23、27、31、35、38、43和47毫克·千克⁻¹·天⁻¹）以及24小时指示氨基酸氧化（24-h IAAO）和24小时指示氨基酸平衡（24-h IAAB）方法，评估营养良好的健康印度人对苯丙氨酸的需求量。

设计

在2个随机分配的6天饮食期内，对32名健康、营养良好的印度男性进行研究，每个饮食期提供19、23、27、31、35、38、43和47毫克·千克⁻¹·天⁻¹的苯丙氨酸摄入量；饮食中不含酪氨酸。在第7天，使用24小时[¹³C]亮氨酸示踪剂输注来测量24小时IAAO和24小时IAAB。确定这些值与苯丙氨酸摄入量之间关系的断点。