用于制备候选药物分子的反应分析。
Analysis of the reactions used for the preparation of drug candidate molecules.
作者信息
Carey John S, Laffan David, Thomson Colin, Williams Mike T
机构信息
GlaxoSmithKline Pharmaceuticals, Old Powder Mills, Tonbridge, UK.
出版信息
Org Biomol Chem. 2006 Jun 21;4(12):2337-47. doi: 10.1039/b602413k. Epub 2006 May 3.
DOI:10.1039/b602413k
PMID:16763676
Abstract
The purpose of this perspective is to indicate the range of chemistries used in the manufacture of drug candidate molecules and to highlight certain gaps in current technologies. To do this a survey was carried out of chemical syntheses within the Process Chemistry R&D departments of GlaxoSmithKline, AstraZeneca and Pfizer.
摘要
本文的目的是指出用于制造候选药物分子的化学方法范围，并突出当前技术中的某些差距。为此，对葛兰素史克、阿斯利康和辉瑞公司工艺化学研发部门内的化学合成进行了一项调查。
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