Chang Yu-Hsiang, Cho Yoon, Shen Weijia, Krische Michael J
University of Texas at Austin, Department of Chemistry Welch Hall (A5300), 105 E 24th St., Austin, TX 78712, USA.
ACS Catal. 2025 May 16;15(10):8274-8283. doi: 10.1021/acscatal.5c01994. Epub 2025 May 2.
Catalytic methods for the intermolecular formate-mediated C-C coupling of Csp-X pronucleophiles beyond reductive Heck reactions (alkene hydroarylations) are catalogued. These methods include transfer hydrogenative reductive couplings of aryl/vinyl halides or triflates to carbonyl compounds (Grignard/NHK-type reactions), as well as reductive cross-couplings of two aryl/vinyl halide or triflate partners. These studies demonstrate that reactions traditionally associated with discrete Csp carbanions can be rendered catalytic and free from premetalated reagents or metallic reductants using sodium or potassium formate - abundant, low molecular weight sources of hydrogen.
除还原Heck反应（烯烃氢芳基化）外，用于Csp-X亲核前体分子间甲酸介导的C-C偶联的催化方法已被分类。这些方法包括芳基/乙烯基卤化物或三氟甲磺酸酯与羰基化合物的转移氢化还原偶联（格氏/NHK型反应），以及两个芳基/乙烯基卤化物或三氟甲磺酸酯底物的还原交叉偶联。这些研究表明，传统上与离散的Csp碳负离子相关的反应可以使用甲酸钠或甲酸钾（丰富、低分子量的氢源）实现催化，且无需预金属化试剂或金属还原剂。
