[Effect of maternal autoimmune thyroid disease on intellectual development of infants].

作者信息

Zhu Hong, Mao Hua-qing, Chen Li-qin, Jiang You-jun

机构信息

Department of Endocrinology, The Affiliated Children's Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.

出版信息

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2006 May;35(3):292-6. doi: 10.3785/j.issn.1008-9292.2006.03.011.

DOI:10.3785/j.issn.1008-9292.2006.03.011

PMID:16764032

Abstract

OBJECTIVE

To study the effect of maternal Hashimoto's disease (an autoimmune thyroid disease) on intellectual development of infants.

METHODS

From July 2001 to June 2003, 21 infants born by mothers suffered from Hashimoto's disease were followed up with provincial neonatal disease screening network system. Their thyroid function was assessed and their mental development was evaluated with Gesell development schedules.

RESULT

(1) Among the 21 infants, 8 showed normal thyroid function, 11 showed hyperthyrotropinemia, 2 cases had congenital hypothyroidism, which showed significant differences from those born by healthy mothers. (2) The mental and psychomotor development of infants whose mothers suffered from Hashimoto's disease lagged behind those with the healthy mothers (P <0.05).