[脉络膜新生血管患者房水中的血管内皮生长因子和色素上皮衍生因子]
[Vascular endothelial growth factor and pigment epithelium-derived factor in aqueous humor of patients with choroidal neovascularization].
作者信息
Tong Jian-ping, Shen Ye, Chan Wai-man, Lin Shun-chao, Peng Zhi-pei
机构信息
Zheyi Eye Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
出版信息
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2006 May;35(3):311-4. doi: 10.3785/j.issn.1008-9292.2006.03.014.
OBJECTIVE
To detect the levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) in aqueous humor of patients with active choroidal neovascularization (CNV).
METHODS
Aqueous humor samples were obtained from 32 patients with active CNV. The concentrations of VEGF and PEDF in aqueous humor were measured by enzyme linked immunosorbent assay (ELISA) for quantitative analysis. VEGF and PEDF in 10 samples of aqueous humor from patients with cataract were also detected by the same methods as control.
RESULT
The mean VEGF and PEDF concentrations in aqueous humor of active CNV patients were higher than those in the control group (P=0.000).
CONCLUSION
The patients with active CNV exhibit significantly higher VEGF and PEDF levels than those in control, indicating that VEGF along with PEDF may modulate the formation of CNV.
目的
检测活动性脉络膜新生血管（CNV）患者房水中血管内皮生长因子（VEGF）和色素上皮衍生因子（PEDF）的水平。
方法
收集32例活动性CNV患者的房水样本。采用酶联免疫吸附测定（ELISA）法检测房水中VEGF和PEDF的浓度进行定量分析。同时采用相同方法检测10例白内障患者房水样本中的VEGF和PEDF作为对照。
结果
活动性CNV患者房水中VEGF和PEDF的平均浓度高于对照组（P = 0.000）。
结论
活动性CNV患者的VEGF和PEDF水平显著高于对照组，表明VEGF和PEDF可能共同调节CNV的形成。
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