眼部血管生成的介质
Mediators of ocular angiogenesis.
作者信息
Qazi Yureeda, Maddula Surekha, Ambati Balamurali K
机构信息
Department of Ophthalmology, John Moran Eye Center, University of Utah, Salt Lake City, UT-84132, USA.
出版信息
J Genet. 2009 Dec;88(4):495-515. doi: 10.1007/s12041-009-0068-0.
Abstract
Angiogenesis is the formation of new blood vessels from pre-existing vasculature. Pathologic angiogenesis in the eye can lead to severe visual impairment. In our review, we discuss the roles of both pro-angiogenic and anti-angiogenic molecular players in corneal angiogenesis, proliferative diabetic retinopathy, exudative macular degeneration and retinopathy of prematurity, highlighting novel targets that have emerged over the past decade.
摘要
血管生成是指从已有的脉管系统形成新的血管。眼部的病理性血管生成会导致严重的视力损害。在我们的综述中，我们讨论了促血管生成和抗血管生成分子在角膜血管生成、增殖性糖尿病视网膜病变、渗出性黄斑变性和早产儿视网膜病变中的作用，重点介绍了过去十年中出现的新靶点。
相似文献
1
Mediators of ocular angiogenesis.眼部血管生成的介质
J Genet. 2009 Dec;88(4):495-515. doi: 10.1007/s12041-009-0068-0.
2
Lipid Signaling in Ocular Neovascularization.脂质信号在眼部新生血管中的作用。
Int J Mol Sci. 2020 Jul 4;21(13):4758. doi: 10.3390/ijms21134758.
3
Nanoparticle-mediated expression of a Wnt pathway inhibitor ameliorates ocular neovascularization.纳米颗粒介导的Wnt信号通路抑制剂表达可改善眼部新生血管形成。
Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):855-64. doi: 10.1161/ATVBAHA.114.304627. Epub 2015 Feb 5.
4
Dual blockade of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (FGF-2) exhibits potent anti-angiogenic effects.血管内皮生长因子（VEGF）和碱性成纤维细胞生长因子（FGF-2）的双重阻断表现出强大的抗血管生成作用。
Cancer Lett. 2016 Jul 28;377(2):164-73. doi: 10.1016/j.canlet.2016.04.036. Epub 2016 Apr 26.
5
MicroRNAs and the HIF/VEGF axis in ocular neovascular diseases.微小 RNA 与眼部新生血管疾病中的 HIF/VEGF 轴。
Acta Ophthalmol. 2021 Dec;99(8):e1255-e1262. doi: 10.1111/aos.14845. Epub 2021 Mar 17.
6
Myeloid-Derived Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor Are Dispensable for Ocular Neovascularization--Brief Report.髓源性血管内皮生长因子和缺氧诱导因子对眼新生血管形成并非必需——简要报告
Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):19-24. doi: 10.1161/ATVBAHA.115.306681. Epub 2015 Nov 24.
7
Both Autocrine Signaling and Paracrine Signaling of HB-EGF Enhance Ocular Neovascularization.HB-EGF 的自分泌信号和旁分泌信号均增强眼部新生血管形成。
Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):174-185. doi: 10.1161/ATVBAHA.117.310337. Epub 2017 Nov 30.
8
Effect of Guibi-Tang, a Traditional Herbal Formula, on Retinal Neovascularization in a Mouse Model of Proliferative Retinopathy.传统中药方剂归脾汤对增殖性视网膜病变小鼠模型视网膜新生血管形成的影响。
Int J Mol Sci. 2015 Dec 16;16(12):29900-10. doi: 10.3390/ijms161226211.
9
Differential hypoxic response of human choroidal and retinal endothelial cells proposes tissue heterogeneity of ocular angiogenesis.人脉络膜和视网膜血管内皮细胞的缺氧反应差异提示眼血管生成的组织异质性。
Acta Ophthalmol. 2016 Dec;94(8):805-814. doi: 10.1111/aos.13119. Epub 2016 Jun 3.
10
Mechanisms of ocular angiogenesis and its molecular mediators.眼部血管生成的机制及其分子介质。
Dev Ophthalmol. 2010;46:4-20. doi: 10.1159/000320006. Epub 2010 Aug 10.
引用本文的文献
1
miR-497 knockout aggravates alkali burn-induced corneal neovascularization via VEGFA and FGF2 pathways in mice models.在小鼠模型中，miR-497基因敲除通过VEGFA和FGF2途径加重碱烧伤诱导的角膜新生血管形成。
Int Ophthalmol. 2025 Aug 12;45(1):328. doi: 10.1007/s10792-025-03691-3.
2
Biochemical Study of Bilberry Extract Potential in Preventing Retinal Damage in Rat Model of Diabetes Induced by Streptozotocin/Nicotinamide.越橘提取物对链脲佐菌素/烟酰胺诱导的糖尿病大鼠模型视网膜损伤预防作用的生化研究
Life (Basel). 2025 Jun 25;15(7):1006. doi: 10.3390/life15071006.
3
Phlorizin Protects Against Oxidative Stress and Inflammation in Age-Related Macular Degeneration Model.根皮苷对年龄相关性黄斑变性模型中的氧化应激和炎症具有保护作用。
Biomolecules. 2025 Apr 3;15(4):523. doi: 10.3390/biom15040523.
4
Ref-1 is overexpressed in neovascular eye disease and targetable with a novel inhibitor.Ref-1在新生血管性眼病中过表达，并且可用一种新型抑制剂进行靶向治疗。
Angiogenesis. 2025 Jan 5;28(1):11. doi: 10.1007/s10456-024-09966-0.
5
Management of corneal neovascularization: Current and emerging therapeutic approaches.角膜新生血管的治疗管理：当前和新兴的治疗方法。
Indian J Ophthalmol. 2024 May 1;72(Suppl 3):S354-S371. doi: 10.4103/IJO.IJO_3043_23. Epub 2024 Apr 20.
6
Serum and Vitreous Levels of Placenta Growth Factor in Diabetic Retinopathy Patients: Correlation With Disease Severity and Optical Coherence Tomographic Parameters.糖尿病视网膜病变患者血清和玻璃体液中胎盘生长因子水平：与疾病严重程度及光学相干断层扫描参数的相关性
Cureus. 2024 Feb 25;16(2):e54862. doi: 10.7759/cureus.54862. eCollection 2024 Feb.
7
Assessment of the Effects of Sphingosine Kinase 1/Sphingosine-1-Phosphate on Microangiogenesis at Rat Myofascial Trigger Points Using Contrast-Enhanced Ultrasonography.使用超声造影评估鞘氨醇激酶1/1-磷酸鞘氨醇对大鼠肌筋膜触发点微血管生成的影响。
J Pain Res. 2024 Feb 12;17:609-621. doi: 10.2147/JPR.S437111. eCollection 2024.
8
Therapeutic effects of a novel venom abstract (ZK002) solution in an alkali-burned corneal wound-healing model.新型毒液摘要（ZK002）溶液在碱性烧伤角膜伤口愈合模型中的治疗效果。
Mol Vis. 2023 Dec 15;29:317-328. eCollection 2023.
9
Identification of immune-related genes in diagnosing retinopathy of prematurity with sepsis through bioinformatics analysis and machine learning.通过生物信息学分析和机器学习鉴定用于诊断伴有败血症的早产儿视网膜病变的免疫相关基因。
Front Genet. 2023 Nov 10;14:1264873. doi: 10.3389/fgene.2023.1264873. eCollection 2023.
10
Immune Mediators Profiles in the Aqueous Humor of Patients with Simple Diabetic Retinopathy.单纯性糖尿病视网膜病变患者房水中的免疫介质谱
J Clin Med. 2023 Nov 5;12(21):6931. doi: 10.3390/jcm12216931.
本文引用的文献
1
Role of alpha 4 integrin (CD49d) in the pathogenesis of diabetic retinopathy.α4整合素（CD49d）在糖尿病视网膜病变发病机制中的作用。
Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4898-904. doi: 10.1167/iovs.08-2013. Epub 2009 Jun 24.
2
Inflammatory cells and chemokines sustain FGF2-induced angiogenesis.炎性细胞和趋化因子维持 FGF2 诱导的血管生成。
Eur Cytokine Netw. 2009 Jun;20(2):39-50. doi: 10.1684/ecn.2009.0155.
3
Investigation of prolactin-related vasoinhibin in sera from patients with diabetic retinopathy.糖尿病视网膜病变患者血清中催乳素相关血管抑制素的研究。
Eur J Endocrinol. 2009 Aug;161(2):345-53. doi: 10.1530/EJE-09-0130. Epub 2009 May 28.
4
Comparative effects of fatty acids on proinflammatory gene cyclooxygenase 2 and inducible nitric oxide synthase expression in retinal pigment epithelial cells.脂肪酸对视网膜色素上皮细胞中促炎基因环氧化酶2和诱导型一氧化氮合酶表达的比较作用。
Mol Nutr Food Res. 2009 Jun;53(6):739-50. doi: 10.1002/mnfr.200800220.
5
HTRA1 promoter polymorphism and risk of age-related macular degeneration: a meta-analysis.HTRA1启动子多态性与年龄相关性黄斑变性风险：一项荟萃分析。
Ann Epidemiol. 2009 Oct;19(10):740-5. doi: 10.1016/j.annepidem.2009.03.002. Epub 2009 Apr 17.
6
Vitreous levels of erythropoietin and vascular endothelial growth factor in eyes with retinopathy of prematurity.早产儿视网膜病变患儿眼内促红细胞生成素和血管内皮生长因子的玻璃体水平
Ophthalmology. 2009 Sep;116(9):1599-603. doi: 10.1016/j.ophtha.2008.12.023. Epub 2009 Apr 15.
7
[Lifestyle-related diseases and anti-aging ophthalmology: suppression of retinal and choroidal pathologies by inhibiting renin-angiotensin system and inflammation].[生活方式相关疾病与抗衰老眼科学：通过抑制肾素-血管紧张素系统和炎症来抑制视网膜和脉络膜病变]
Nippon Ganka Gakkai Zasshi. 2009 Mar;113(3):403-22; discussion 423.
8
Diabetic retinopathy: a growing concern in an aging population.糖尿病视网膜病变：老龄化人群中日益受到关注的问题。
Geriatrics. 2009 Feb;64(2):16-20.
9
Diabetic retinopathy and angiogenesis.糖尿病视网膜病变与血管生成
Curr Diabetes Rev. 2009 Feb;5(1):8-13. doi: 10.2174/157339909787314149.
10
Complement component C3 and risk of age-related macular degeneration.补体成分C3与年龄相关性黄斑变性的风险
Ophthalmology. 2009 Mar;116(3):474-480.e2. doi: 10.1016/j.ophtha.2008.09.055. Epub 2009 Jan 24.
Zotero 插件