Schlech B A, Hansard J D, Bach F C
Ann Ophthalmol. 1975 Jul;7(7):967-77.
Combinations of neomycin sulfate and polymyxin B sulfate are commonly used in ophthalmic ointments for the treatment or the prevention of bacterial keratoconjunctivitis. In this study we evaluated the effectiveness of various ointments containing these two antibiotics, alone and in combination, in preventing Staphylococcus aureus keratitis in rabbits. Rabbit eyes were infected by intracorneal inoculation, treated topically with ointment and graded by gross observation 24 hours after inoculation. Treatment with ointments containing neomycin alone offered significant protection against these corneal infections. The polymyxin B ointments, as well as the vehicle controls, were ineffective in preventing S aureus infections in the rabbit eyes. However, by far, the most effective ointment formulations tested were the combination ointments and specifically those containing 1.75-3.50 mg neomycin and 3,000-6,000 units polymycin B per gram of ointment.
硫酸新霉素和硫酸多粘菌素B的组合常用于眼科软膏，以治疗或预防细菌性角膜结膜炎。在本研究中，我们评估了单独或联合使用这两种抗生素的各种软膏预防兔金黄色葡萄球菌角膜炎的有效性。通过角膜内接种感染兔眼，局部用软膏治疗，并在接种后24小时通过肉眼观察进行分级。单独使用含新霉素的软膏治疗对这些角膜感染提供了显著的保护作用。多粘菌素B软膏以及赋形剂对照在预防兔眼金黄色葡萄球菌感染方面无效。然而，迄今为止，测试的最有效的软膏配方是复方软膏，特别是每克软膏含1.75 - 3.50毫克新霉素和3000 - 6000单位多粘菌素B的复方软膏。
