Wiederstein Iris, Auer Ulrike, Moens Yves
Department of Companion Animals and Horses, Clinic for Anaesthesiology and Perioperative Intensive Care, University of Veterinary Medicine Vienna, Vienna, Austria.
Vet Anaesth Analg. 2006 Jul;33(4):201-6. doi: 10.1111/j.1467-2995.2005.00254.x.
To compare the doses of propofol required for insertion of the laryngeal mask airway (LMA) with those for endotracheal intubation in sedated dogs.
Randomized prospective clinical study. Animals Sixty healthy dogs aged 0.33-8.5 (3.0 +/- 2.3, mean +/- SD) years, weighing 2.2-59.0 (23.4 +/- 13.6, mean +/- SD) kg, presented for elective surgery requiring inhalation anaesthesia.
Animals were randomly assigned to receive either a LMA or an endotracheal tube. Pre-anaesthetic medication was intravenous (IV) glycopyrrolate (0.01 mg kg(-1)) medetomidine (10 microg kg(-1)) and butorphanol (0.2 mg kg(-1)). Repeated IV propofol injections (1 mg kg(-1) in 30 seconds) were given until LMA insertion or endotracheal intubation was achieved, when the presence or absence of laryngospasm, the respiratory rate (fr) and the total dose of propofol used were recorded.
The total propofol dose (mean +/- SD) required for LMA insertion (0.53 +/- 0.51 mg kg(-1)) was significantly lower than for endotracheal intubation (1.43 +/- 0.57 mg kg(-1)). The LMA could be inserted without propofol in 47% of dogs; the remainder needed a single 1 mg kg(-1) bolus (n = 30). Endotracheal intubation was possible without propofol in 3.3% of the dogs, 47% needed one bolus and 50% required two injections (n = 30). The f(r) (mean +/- SD) was 18 +/- 6 and 15 +/- 7 minute(-1) after LMA insertion and intubation, respectively.
Laryngeal mask airway insertion requires less propofol than endotracheal intubation in sedated dogs therefore propofol-induced cardiorespiratory depression is likely to be less severe. The LMA is well tolerated and offers a less invasive means of securing the upper airway.
比较镇静犬插入喉罩气道(LMA)与气管插管所需的丙泊酚剂量。
随机前瞻性临床研究。动物60只健康犬,年龄0.33 - 8.5(3.0±2.3,平均±标准差)岁,体重2.2 - 59.0(23.4±13.6,平均±标准差)kg,因需要吸入麻醉的择期手术就诊。
将动物随机分配接受LMA或气管导管。麻醉前用药为静脉注射(IV)格隆溴铵(0.01 mg kg⁻¹)、美托咪定(10 μg kg⁻¹)和布托啡诺(0.2 mg kg⁻¹)。重复静脉注射丙泊酚(30秒内1 mg kg⁻¹),直至成功插入LMA或气管插管,记录是否存在喉痉挛、呼吸频率(fr)以及所用丙泊酚的总剂量。
插入LMA所需的丙泊酚总剂量(平均±标准差)(0.53±0.51 mg kg⁻¹)显著低于气管插管(1.43±0.57 mg kg⁻¹)。47%的犬无需丙泊酚即可插入LMA;其余犬需要单次1 mg kg⁻¹推注(n = 30)。3.3%的犬无需丙泊酚即可进行气管插管,47%的犬需要一次推注,50%的犬需要两次注射(n = 30)。插入LMA和插管后,fr(平均±标准差)分别为18±6和15±7次/分钟。
在镇静犬中,插入喉罩气道所需的丙泊酚比气管插管少,因此丙泊酚引起的心肺抑制可能较轻。喉罩气道耐受性良好,提供了一种侵入性较小的确保上呼吸道通畅的方法。