Nemet Arie Y, Sharma Vidushi, Benger Ross
Clin Exp Ophthalmol. 2006 May-Jun;34(4):375-7. doi: 10.1111/j.1442-9071.2006.01226.x.
Three patients had residual or recurrent tumour following excision of large ocular surface squamous neoplasia (OSSN) lesions, which did not resolve despite the use of adjunctive cryotherapy and topical mitomycin-C therapy. The residual tumour was treated with topical or subconjunctival injectable interferon alpha 2b. All three eyes had complete resolution of the OSSN lesions after an average of 6 weeks (range 4-8 weeks) of treatment with interferon alpha 2b. No regrowth was seen during the follow-up period of 22.7 +/- 32.3 months (range 5-60 months). No adverse reactions or complaints were reported during and following interferon use, and previous symptoms from mitomycin-C treatment resolved completely. In these patients subconjunctival or topical interferon was an effective and safe treatment for residual OSSN. Longer follow up is required to confirm the long-term efficacy in prevention of recurrences.
三名患者在切除大面积眼表鳞状上皮肿瘤（OSSN）病变后出现残留或复发性肿瘤，尽管采用了辅助冷冻疗法和局部丝裂霉素-C治疗，但病变仍未消退。残留肿瘤采用局部或结膜下注射干扰素α-2b进行治疗。在用干扰素α-2b治疗平均6周（范围4-8周）后，所有三只眼睛的OSSN病变均完全消退。在22.7±32.3个月（范围5-60个月）的随访期内未见肿瘤复发。在使用干扰素期间及之后均未报告不良反应或不适主诉，丝裂霉素-C治疗引起的既往症状也完全消失。对于残留的OSSN，结膜下或局部使用干扰素是一种有效且安全的治疗方法。需要更长时间的随访来确认其预防复发的长期疗效。
