Bagley Daniel M, Casterton Phillip L, Dressler William E, Edelhauser Henry F, Kruszewski Francis H, McCulley James P, Nussenblatt Robert B, Osborne Rosemarie, Rothenstein Arthur, Stitzel Katherine A, Thomas Karluss, Ward Sherry L
Colgate-Palmolive Company, Piscataway, NJ, USA.
Regul Toxicol Pharmacol. 2006 Jul;45(2):206-13. doi: 10.1016/j.yrtph.2006.04.005. Epub 2006 Jun 9.
Various ocular alkali burn classification schemes have been published and used to grade human chemical eye injuries for the purpose of identifying treatments and forecasting outcomes. The ILSI chemical eye injury classification scheme was developed for the additional purpose of collecting detailed human eye injury data to provide information on the mechanisms associated with chemical eye injuries. This information will have clinical application, as well as use in the development and validation of new methods to assess ocular toxicity.
A panel of ophthalmic researchers proposed the new classification scheme based upon current knowledge of the mechanisms of eye injury, and their collective clinical and research experience. Additional ophthalmologists and researchers were surveyed to critique the scheme. The draft scheme was revised, and the proposed scheme represents the best consensus from at least 23 physicians and scientists.
The new scheme classifies chemical eye injury into five categories based on clinical signs, symptoms, and expected outcomes. Diagnostic classification is based primarily on two clinical endpoints: (1) the extent (area) of injury at the limbus, and (2) the degree of injury (area and depth) to the cornea.
The new classification scheme provides a uniform system for scoring eye injury across chemical classes, and provides enough detail for the clinician to collect data that will be relevant to identifying the mechanisms of ocular injury.
已发表了多种眼部碱烧伤分类方案，并用于对人类化学性眼损伤进行分级，以确定治疗方法并预测预后。国际生命科学学会（ILSI）化学性眼损伤分类方案的制定还有一个额外目的，即收集详细的人类眼损伤数据，以提供与化学性眼损伤相关机制的信息。这些信息将具有临床应用价值，也可用于开发和验证评估眼毒性的新方法。
一组眼科研究人员根据当前对眼损伤机制的了解以及他们的临床和研究经验，提出了新的分类方案。还对其他眼科医生和研究人员进行了调查，以对该方案进行评估。对草案进行了修订，所提出的方案代表了至少23位医生和科学家的最佳共识。
新方案根据临床体征、症状和预期结果将化学性眼损伤分为五类。诊断分类主要基于两个临床终点：（1）角膜缘损伤的范围（面积），以及（2）角膜损伤的程度（面积和深度）。
新的分类方案提供了一个统一的系统，用于对不同化学类别导致的眼损伤进行评分，并为临床医生提供了足够的细节，以便收集与确定眼损伤机制相关的数据。
