Tochigi Mamoru, Otowa Takeshi, Hibino Hiroyuki, Kato Chieko, Marui Tetsuya, Ohtani Toshiyuki, Umekage Tadashi, Kato Nobumasa, Sasaki Tsukasa
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan.
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Aug 30;30(6):1122-4. doi: 10.1016/j.pnpbp.2006.04.019. Epub 2006 Jun 9.
Clara cell secretory protein (CC16) is an anti-inflammatory protein expressed in the respiratory tract. Several studies have suggested the association between CC16 and mental disturbances, such as schizophrenia, depression, and post-traumatic stress disorder. In the present study, we investigated the association between the CC16 gene A38G polymorphism and personality traits in 214 healthy Japanese subjects. Personality traits were evaluated by using the Revised NEO Personality Inventory (NEO PI-R) and the State-Trait Anxiety Inventory (STAI). As a result, no significant association was observed between the genotypes and the scores of the NEO PI-R or the STAI. The present results suggest that CC16 may not have a major role in the development of personality traits.
克拉拉细胞分泌蛋白（CC16）是一种在呼吸道表达的抗炎蛋白。多项研究表明CC16与精神障碍之间存在关联，如精神分裂症、抑郁症和创伤后应激障碍。在本研究中，我们调查了214名健康日本受试者中CC16基因A38G多态性与人格特质之间的关联。人格特质通过使用修订版的大五人格量表（NEO PI-R）和状态-特质焦虑量表（STAI）进行评估。结果显示，基因型与NEO PI-R或STAI的得分之间未观察到显著关联。目前的结果表明，CC16可能在人格特质的发展中不起主要作用。
