Kopelman Doron, Inbar Yael, Hanannel Arik, Freundlich David, Vitek Shuki, Schmidt Rita, Sokolov Amit, Hatoum Ossama A, Rabinovici Jaron
Department of Surgery B, HaEmek Medical Center, Afula, Israel.
Eur J Radiol. 2006 Aug;59(2):190-7. doi: 10.1016/j.ejrad.2006.04.018. Epub 2006 Jun 9.
To evaluate the safety and efficacy of an enhanced magnetic resonance-guided focused ultrasound (MRgFUS) emission protocol that results in more extensive treatment by increasing the volume of each focal ablation using the same energy.
Six pigs were treated with an MRgFUS system combined with real-time MR, for imaging and temperature mapping, with 102 "enhanced" and 97 "regular" focal ablations performed on both buttock muscles. Real-time imaging, temperature mapping, and acoustic reflected spectrum data enabled immediate evaluation of the results. MR contrast-enhanced images and pathology examinations were used for confirmation.
The location of the ablated volume by "enhanced" sonication is predictable, with a maximum possible shift of 6 mm toward, and 3 mm away, from the transducer. The ablated volume after enhanced sonication was, on average, 1.8 times larger than after a regular sonication of the same energy. Pathology results showed the same thermally induced damage patterns in the enhanced sonications and the regular sonications.
Accelerated MRgFUS with enhanced sonication is a safe, controllable, and more effective tissue ablative modality than standard sonication. This new technology may significantly reduce the length of tumor ablation procedures. (Isn't the new technology you're talking about MRgFUS? If so, you don't need to repeat it at the end of this sentence.).
评估一种增强型磁共振引导聚焦超声（MRgFUS）发射方案的安全性和有效性，该方案通过在使用相同能量的情况下增加每个焦点消融的体积来实现更广泛的治疗。
六头猪接受了结合实时磁共振成像（用于成像和温度映射）的MRgFUS系统治疗，在双侧臀部肌肉上进行了102次“增强型”和97次“常规”焦点消融。实时成像、温度映射和声反射光谱数据能够立即评估结果。使用磁共振对比增强图像和病理检查进行确认。
“增强型”超声处理后的消融体积位置可预测，最大可能向换能器方向偏移6毫米，远离换能器方向偏移3毫米。增强型超声处理后的消融体积平均比相同能量的常规超声处理后的消融体积大1.8倍。病理结果显示，增强型超声处理和常规超声处理中热诱导损伤模式相同。
与标准超声处理相比，增强型超声处理的加速MRgFUS是一种安全、可控且更有效的组织消融方式。这项新技术可能会显著缩短肿瘤消融手术的时间。
