Browning Robert E Lee, Li Hecheng, Shinohara Eric T, Cai Qiuyin, Chen Heidi, Courtney Regina, Cao Carolyn, Zheng Wei, Lu Bo
Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
Urology. 2006 Jun;67(6):1320-3. doi: 10.1016/j.urology.2005.12.012.
ATM is an important protein that protects the genome from double-stranded DNA breaks. Mutations and polymorphisms in the ATM gene have been associated with an increased risk of certain types of malignancies, especially breast cancer.
We analyzed tissue from 98 white patients with prostate cancer for the presence of IVS62+60G>A polymorphism in the ATM gene.
The frequency of the homozygous IVS62+60G/G, heterozygous IVS62+60G/A, and homozygous IVS62+60A/A was 18.37% (18 of 98), 30.61% (30 of 98), and 51.02% (50 of 98), respectively. Using Fisher's exact test, we found the polymorphism IVS62+60G>A was not significantly related to age, tumor grade, prostate-specific antigen level, or clinical stage (P >0.05). No difference was found in relapse-free survival between patients with IVS62+60G/G and those with IVS62+60G/A or IVS62+60A/A (P = 0.4533).
The results of our study indicate that this ATM polymorphism is not associated with the aggressiveness of prostate cancer in white men.
ATM是一种重要的蛋白质，可保护基因组免受双链DNA断裂的影响。ATM基因的突变和多态性与某些类型恶性肿瘤尤其是乳腺癌的风险增加有关。
我们分析了98例白人前列腺癌患者的组织，以检测ATM基因中IVS62 + 60G>A多态性的存在情况。
纯合子IVS62 + 60G/G、杂合子IVS62 + 60G/A和纯合子IVS62 + 60A/A的频率分别为18.37%（98例中的18例）、30.61%（98例中的30例）和51.02%（98例中的50例）。使用Fisher精确检验，我们发现多态性IVS62 + 60G>A与年龄、肿瘤分级、前列腺特异性抗原水平或临床分期无显著相关性（P>0.05）。IVS62 + 60G/G患者与IVS62 + 60G/A或IVS62 + 60A/A患者的无复发生存率无差异（P = 0.4533）。
我们的研究结果表明，这种ATM多态性与白人男性前列腺癌的侵袭性无关。
