Boulanger Denis, Dieng Yemou, Cisse Badara, Remoue Franck, Capuano Frederic, Dieme Jean-Louis, Ndiaye Tofene, Sokhna Cheikh, Trape Jean-François, Greenwood Brian, Simondon Francois
Institut de Recherche pour le Développement, UR024, Dakar, Senegal and Montpellier, France.
Trans R Soc Trop Med Hyg. 2007 Feb;101(2):113-6. doi: 10.1016/j.trstmh.2006.03.003. Epub 2006 Jun 12.
Artesunate is a highly effective antimalarial and there is some evidence that it is also active against schistosome infections. We therefore investigated whether treatment with artesunate of acute malaria in Senegalese children had an impact on their level of infection with Schistosoma haematobium. Twenty-seven children who were entered into a clinical trial of antimalaria treatment were excreting S. haematobium eggs in their urine on the day of treatment. Fifteen children received a combination of a single dose of sulfadoxine/pyrimethamine together with three daily doses of artesunate (4 mg/kg); the remaining 12 children received three daily doses of amodiaquine and artesunate. The overall cure rate and reduction in the mean number of excreted eggs at 28 days post treatment were 92.6% and 94.5%, respectively. Our findings indicate that artesunate, in addition to being a very effective treatment for uncomplicated malaria, can also sharply reduce the S. haematobium loads harboured by pre-school African children.
青蒿琥酯是一种高效抗疟药，并且有证据表明它对血吸虫感染也有活性。因此，我们研究了塞内加尔儿童急性疟疾患者接受青蒿琥酯治疗是否会对其埃及血吸虫感染水平产生影响。27名参加抗疟治疗临床试验的儿童在治疗当天尿液中排出埃及血吸虫卵。15名儿童接受了单剂量磺胺多辛/乙胺嘧啶与每日3次青蒿琥酯（4毫克/千克）联合治疗；其余12名儿童接受了每日3次阿莫地喹和青蒿琥酯治疗。治疗后28天的总体治愈率以及排出虫卵平均数量的减少率分别为92.6%和94.5%。我们的研究结果表明，青蒿琥酯除了作为单纯性疟疾的非常有效的治疗药物外，还可以大幅降低非洲学龄前儿童体内的埃及血吸虫负荷。
