存在于由泰勒氏病毒诱导的脱髓鞘病变中的效应T淋巴细胞。
Effector T lymphocytes present in demyelinating lesions induced by Theiler's virus.
作者信息
Cash E, Bandeira A
机构信息
Laboratory of Slow Viruses, Pasteur Institute, Paris, France.
出版信息
Viral Immunol. 1991 Spring;4(1):53-7. doi: 10.1089/vim.1991.4.53.
Theiler's virus causes chronic primary demyelination associated with viral persistence in SJL/J mice. We have investigated the effector functions of T lymphocytes isolated from inflammatory brain lesions to detect a local immune dysfunction associated with viral persistence. In vitro, CD4+ T cells induced B-lymphocyte proliferation and antibody secretion; CD8+ T cells had cytolytic activity. Therefore, Theiler's virus persistence does not include local immune unresponsiveness.
泰勒氏病毒会在SJL/J小鼠中引发与病毒持续存在相关的慢性原发性脱髓鞘病变。我们研究了从炎性脑损伤中分离出的T淋巴细胞的效应功能，以检测与病毒持续存在相关的局部免疫功能障碍。在体外，CD4+ T细胞可诱导B淋巴细胞增殖和抗体分泌；CD8+ T细胞具有细胞溶解活性。因此，泰勒氏病毒的持续存在并不包括局部免疫无反应性。
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