Rundqvist Jonas, Hoh Jan H, Haviland David B
Nanostructure Physics, AlbaNova University Center, Royal Institute of Technology, Roslagsvägen 30 B, SE-106 91 Stockholm, Sweden.
J Colloid Interface Sci. 2006 Sep 1;301(1):337-41. doi: 10.1016/j.jcis.2006.05.012. Epub 2006 May 6.
Poly(ethylene glycol) (PEG) self-assembled monolayers (SAMs) are surface coatings that efficiently prevent nonspecific adhesion of biomolecules to surfaces. Here, we report on SAM formation of the PEG thiol CH3O(CH2CH2O)17NHCO(CH2)2SH (PEG(17)) on three types of Au films: thermally evaporated granular Au and two types of Au films from hydrogen flame annealing of granular Au, Au(111), and Au silicide. The different Au surfaces clearly affects the morphology and mechanical properties of the PEG(17) SAM, which is shown by AFM topographs and force distance curves. The two types of SAMs found on flame-annealed Au were denoted "soft" and "hard" due to their difference in stiffness and resistance to scratching by the AFM probe. With the aim of nanometer scale patterning of the PEG(17), the SAMs were exposed by low energy (1 kV) electron beam lithography (EBL). Two distinctly different types of behaviour were observed on the different types of SAM; the soft PEG(17) SAM was destroyed in a self-developing process while material deposition was dominant for the hard PEG(17) SAM.
聚乙二醇（PEG）自组装单分子层（SAMs）是一种能有效防止生物分子非特异性粘附于表面的表面涂层。在此，我们报道了PEG硫醇CH3O(CH2CH2O)17NHCO(CH2)2SH（PEG(17)）在三种类型金膜上形成SAMs的情况：热蒸发颗粒状金以及通过颗粒状金、Au(111)和硅化金的氢火焰退火得到的两种类型金膜。不同的金表面明显影响了PEG(17) SAMs的形态和力学性能，这通过原子力显微镜（AFM）形貌图和力-距离曲线得以体现。由于在火焰退火金表面发现的两种类型SAMs在刚度和抗AFM探针刮擦能力上存在差异，因此分别被标记为“软”和“硬”。为了实现PEG(17)的纳米级图案化，通过低能（1 kV）电子束光刻（EBL）对SAMs进行曝光。在不同类型的SAMs上观察到了两种截然不同的行为；软PEG(17) SAM在自显影过程中被破坏，而硬PEG(17) SAM则以材料沉积为主。
