Brunso-Bechtold Judy K, Evans Stephanie D, Henkel Craig K
Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC 27157-1010, USA.
Hear Res. 2006 Aug;218(1-2):1-4. doi: 10.1016/j.heares.2006.03.017. Epub 2006 Jun 12.
Although intrinsic organization in the inferior colliculus (IC) has been surveyed in a variety of species, current knowledge of synaptogenesis within the mammalian inferior colliculus is limited. The present study surveyed the ultrastructure of the central nucleus of the inferior colliculus in postnatal day (P) P4, P7, P14, and P28 ferrets, prior to the onset of hearing at the end of the first postnatal month with the goal of beginning to characterize the time course of synapse formation in relation to the development of afferent projection patterns within the IC. Results suggest that initial synaptogenesis has occurred in the IC by P4 and continues during the period when maturation of the distribution of axons from brainstem auditory nuclei is taking place.
尽管已经在多种物种中研究了下丘（IC）的内在组织，但目前对哺乳动物下丘内突触发生的了解仍然有限。本研究观察了出生后第4天（P4）、第7天（P7）、第14天（P14）和第28天雪貂下丘中央核的超微结构，此时距离出生后第一个月末听力开始还有一段时间，目的是开始描述与下丘内传入投射模式发育相关的突触形成的时间进程。结果表明，到P4时，下丘内已发生初始突触形成，并在脑干听觉核轴突分布成熟的时期持续进行。
