Toyama Tatsuya, Zhang Zhenhuan, Iwase Hirotaka, Yamashita Hiroko, Ando Yoshiaki, Hamaguchi Maho, Mizutani Mitsuhiro, Kondo Naoto, Fujita Takashi, Fujii Yoshitaka, Iwata Hiroji
Department of Breast Oncology, Aichi Cancer Center Hospital, Japan.
Jpn J Clin Oncol. 2006 Jun;36(6):357-63. doi: 10.1093/jjco/hyl038. Epub 2006 Jun 9.
While Snail is a zinc-finger transcription factor that triggers the epithelial-mesenchymal transition, it has also been reported to be indirectly regulated by estrogen receptor alpha (ERalpha) and to be involved in the transcriptional repression of the aromatase gene. The aim of the present study was to examine the role of Snail expression in node-negative invasive ductal carcinomas.
We analyzed Snail mRNA expression levels in 86 node-negative invasive ductal carcinomas by real-time quantitative RT-PCR and studied whether Snail mRNA expression correlates with clinicopathological factors.
No correlation was found between Snail mRNA expression and ERalpha protein expression levels. However, we observed that none of the 34 patients showing low Snail mRNA expression developed distant metastasis while 6 of 52 (12%) showing high expression of Snail mRNA did. The level of Snail mRNA expression was not found to be significantly correlated with clinicopathological factors. No inverse correlation was found between the Snail and aromatase mRNA expression levels in our series.
Our data show that low expression of Snail mRNA is a good prognostic factor in node-negative invasive ductal carcinomas. Snail expression is suggested to be involved in distant metastasis in node-negative invasive ductal carcinomas.
虽然Snail是一种触发上皮-间质转化的锌指转录因子，但也有报道称它受雌激素受体α（ERα）间接调控，并参与芳香化酶基因的转录抑制。本研究的目的是探讨Snail表达在淋巴结阴性浸润性导管癌中的作用。
我们通过实时定量逆转录聚合酶链反应分析了86例淋巴结阴性浸润性导管癌中Snail mRNA的表达水平，并研究Snail mRNA表达是否与临床病理因素相关。
未发现Snail mRNA表达与ERα蛋白表达水平之间存在相关性。然而，我们观察到，34例Snail mRNA表达低的患者均未发生远处转移，而52例（12%）Snail mRNA表达高的患者中有6例发生了远处转移。未发现Snail mRNA表达水平与临床病理因素有显著相关性。在我们的研究系列中，未发现Snail与芳香化酶mRNA表达水平呈负相关。
我们的数据表明，Snail mRNA低表达是淋巴结阴性浸润性导管癌的一个良好预后因素。提示Snail表达参与淋巴结阴性浸润性导管癌的远处转移。
