Kikuchi S, Aramaki Y, Nonaka H, Tsuchiya S
Tokyo College of Pharmacy, Japan.
J Pharm Pharmacol. 1991 Apr;43(4):292-3. doi: 10.1111/j.2042-7158.1991.tb06690.x.
The effect of dextran sulphate on accumulation of gentamicin within the renal cortex and on renal functional changes induced by gentamicin has been investigated using the rat renal perfusion technique. Gentamicin accumulation decreased by the coadministration of dextran sulphate, the degree being proportional to dextran sulphate concentration. The filtered load of gentamicin was unaffected by dextran sulphate. The perfusion of kidney with gentamicin brought about a decrease in the reabsorption of Na+ and an increase in the rate of urine flow with no effect on that of glomerular filtration. The addition of dextran sulphate in the perfusate resulted in the resumption of these levels to those of the control. Dextran sulphate thus apparently interacts with gentamicin in the lumen of proximal tubules to inhibit the reabsorption of gentamicin by proximal tubular cells, and prevents the renal dysfunctions induced by gentamicin.
利用大鼠肾脏灌注技术，研究了硫酸葡聚糖对庆大霉素在肾皮质内蓄积以及对庆大霉素所致肾功能变化的影响。同时给予硫酸葡聚糖可使庆大霉素蓄积减少，减少程度与硫酸葡聚糖浓度成正比。硫酸葡聚糖不影响庆大霉素的滤过负荷。用庆大霉素灌注肾脏可导致Na+重吸收减少、尿流率增加，而对肾小球滤过率无影响。在灌注液中加入硫酸葡聚糖可使这些指标恢复到对照水平。因此，硫酸葡聚糖显然在近端小管管腔内与庆大霉素相互作用，抑制近端小管细胞对庆大霉素的重吸收，并防止庆大霉素所致的肾功能障碍。
