利血平治疗后，蓝斑中神经肽Y和酪氨酸羟化酶的mRNA水平呈现相似的升高。
Neuropeptide Y and tyrosine hydroxylase mRNA levels in the locus coeruleus show similar increases after reserpine treatment.
作者信息
Foster O J, Biswas S, Lightman S L
机构信息
Neuroendocrinology Unit, Charing Cross Hospital, London, UK.
出版信息
Neuropeptides. 1991 Mar;18(3):137-41. doi: 10.1016/0143-4179(91)90105-r.
In situ hybridisation histochemistry was used to study the effect of intra-peritoneal reserpine administration on messenger RNA (mRNA) levels in the locus coeruleus (LC) of the rat. 48h after injection, levels of mRNA encoding tyrosine hydroxylase (TH) and neuropeptide Y (NPY) in the LC increased to approximately 250% of control values (p less than 0.05). The level of beta-tubulin mRNA was unaffected by reserpine administration. The similar and selective increase in TH and NPY mRNA in the LC following reserpine administration suggests that NPY may play a role in the neurotransmitter function of this catecholaminergic nucleus.
采用原位杂交组织化学技术研究腹腔注射利血平对大鼠蓝斑（LC）中信使核糖核酸（mRNA）水平的影响。注射后48小时，LC中编码酪氨酸羟化酶（TH）和神经肽Y（NPY）的mRNA水平增加至对照值的约250%（p<0.05）。β-微管蛋白mRNA水平不受利血平给药的影响。利血平给药后LC中TH和NPY mRNA的相似且选择性增加表明，NPY可能在这个儿茶酚胺能核团的神经递质功能中发挥作用。
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