Scanlan Victoria F, Byrnes Elizabeth M, Bridges Robert S
Department of Biomedical Sciences, Tufts University, MA 01536, USA.
Behav Neurosci. 2006 Jun;120(3):676-86. doi: 10.1037/0735-7044.120.3.676.
The maternal and neurobiological responses of biological mothers and pup-induced maternal virgin rats were compared 55 and 80 days after an initial 2-day maternal experience. When tested for home cage responsiveness after prolonged isolation from young, the biological, primiparous rats displayed shorter maternal latencies. Primiparous females tested in the presence of pups on the elevated plus-maze displayed increased exploration of the open arms and increased c-Fos expression in the cortical nucleus of the amygdala. Pup exposure and parity also enhanced activation of the nucleus accumbens shell and medial nucleus of the amygdala, respectively. Therefore, although both nulliparous and primiparous rats retain a maternal memory for a prolonged time, the memory and neurochemical response appear stronger in primiparous mothers.
在经历了为期2天的初次育幼体验后的55天和80天，对亲生母鼠和由幼崽诱导产生母性的处女鼠的母体反应和神经生物学反应进行了比较。当在与幼崽长期隔离后测试其在笼内的反应性时，初产的亲生母鼠表现出较短的母性潜伏期。在高架十字迷宫中，当着幼崽的面进行测试时，初产雌性对开放臂的探索增加，杏仁核皮质核中的c-Fos表达增加。接触幼崽和产次分别增强了伏隔核壳部和杏仁核内侧核的激活。因此，尽管未生育和初产的大鼠都能长时间保留母性记忆，但初产母鼠的记忆和神经化学反应似乎更强。
