Neumann Bjarne, Gregersen Henrik
Aalborg Sygehus, Kaebekirurgisk Afdeling og Medicinsk Haematologisk Afdeling, Alborg.
Ugeskr Laeger. 2006 May 22;168(21):2078-9.
Osteonecrosis of the jaws in patients on chronic bisphosphonate therapy has been reported in small series since 2003. We present two patients with multiple myeloma who developed osteonecrosis of the jaws on intravenous treatment with zolendronic acid and pamidronate, respectively. The patients were treated with debridement of the involved bone and long-term antibiotic therapy.
自2003年以来，已有小规模系列报道称慢性双膦酸盐治疗患者会发生颌骨坏死。我们报告了两名分别在接受唑来膦酸和帕米膦酸静脉治疗时发生颌骨坏死的多发性骨髓瘤患者。这两名患者均接受了受累骨清创术及长期抗生素治疗。
