一名患有肛门闭锁和直肠尿道瘘的新生儿腔内胎粪结石的红外分光光度法

Infrared spectrophotometry of intraluminal meconium calculi in a neonate with imperforate anus and rectourethral fistula.

作者信息

Shimotake Takashi, Higuchi Kohji, Tsuda Tomoki, Aoi Shigeyoshi, Iwai Naomi

机构信息

Division of Surgery, Children's Research Hospital, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan.

出版信息

J Pediatr Surg. 2006 Jun;41(6):1173-6. doi: 10.1016/j.jpedsurg.2006.01.067.

DOI:10.1016/j.jpedsurg.2006.01.067

PMID:16769356

Abstract

BACKGROUND/PURPOSE: Intraluminal meconium calculi are a rare cause of neonatal abdominal calcifications in patients with anorectal malformations. To investigate their pathogenesis, we performed infrared spectroscopic analysis of meconium-calcified lesions.

METHODS

Meconium calculi were collected from the colostomy in a newborn patient with imperforate anus and rectourethral fistula. The potassium bromide method was employed to obtain the infrared absorption spectrum of the meconium calculi.

RESULTS

The wavelength pattern of the meconium calculi exhibited 4 specific peaks at 1570, 1390, 1105, and 1005 cm(-1) between 22% and 45% transmittance values. The unique absorption spectrum exclusively indicated ammonium hydrogen urate (C(5)N(5)O(3)H(7)), having the combined constituents of ammonium and uric acid.

CONCLUSIONS

These results suggest that the intraluminal meconium calculi were originally derived from meconium and fetal urine. The stasis of meconium passage and fetal urine mixing through the rectourethral fistula in a low-pH condition was deduced to be the main cause of this rare stone formation.

摘要

背景/目的：管腔内胎粪结石是肛门直肠畸形患者新生儿腹部钙化的罕见原因。为了研究其发病机制，我们对胎粪钙化病变进行了红外光谱分析。