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流式细胞术与骨髓活检检测慢性淋巴细胞白血病微小残留病的敏感性比较

A comparison of the sensitivity of flow cytometry and bone marrow biopsy in the detection of minimal residual disease in chronic lymphocytic leukemia.

作者信息

Maloum Karim, Charlotte Frédéric, Divine Marine, Cazin Bruno, Lesty Claude, Merle-Béral Hélène

出版信息

Haematologica. 2006 Jun;91(6):860-1.

PMID:16769593
Abstract

We compared the sensitivity of bone marrow biopsy to blood flow cytometry in detecting minimal residual disease (MRD) in 29 patients with chronic lymphocytic leukemia (CLL) in clinical remission after treatment. These results demonstrate that flow cytometry is more sensitive than bone marrow biopsy in detecting MRD and in predicting relapse in CLL.

摘要

我们比较了骨髓活检与血流式细胞术在检测29例治疗后处于临床缓解期的慢性淋巴细胞白血病（CLL）患者微小残留病（MRD）方面的敏感性。这些结果表明，在检测CLL的MRD及预测复发方面，流式细胞术比骨髓活检更敏感。

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引用本文的文献

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Eradication of minimal residual disease in chronic lymphocytic leukemia.慢性淋巴细胞白血病微小残留病灶的消除。
Curr Hematol Malig Rep. 2008 Jan;3(1):54-60. doi: 10.1007/s11899-008-0009-7.
2
How and why minimal residual disease studies are necessary in leukemia: a review from WP10 and WP12 of the European LeukaemiaNet.白血病中微小残留病研究为何必要及如何开展：来自欧洲白血病网WP10和WP12的综述
Haematologica. 2009 Aug;94(8):1135-50. doi: 10.3324/haematol.2008.004267. Epub 2009 Jul 7.