牛甲状旁腺激素（1-34）、异丙肾上腺素和普萘洛尔对海龟心脏的作用

Cardiac actions of bovine parathyroid hormone (1-34), isoproterenol, and propranolol in turtles.

Nichols J R, Eberts E G

Department of Biology, Abilene Christian University, Texas 79699.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1991;98(2-3):467-70. doi: 10.1016/0742-8413(91)90235-l.

Abstract

In isolated turtle hearts bovine parathyroid hormone (b-PTH) (1-34) stimulated both force of contraction and rate (beats/min) apparently stimulating beats/min to a larger extent. 2. Isoproterenol stimulated both rate and force, perhaps affecting contractile force more. 3. Propranolol alone clearly decreased contractile force and beats/min. 4. Pre-treatment with propranolol removed stimulatory effects of both bPTH (1-34) and isoproterenol. Propranolol's effect on isoproterenol was expected. Its effect on bPTH (1-34) may be related to beta-stimulation by PTH or to some other non-specific inhibitory effect of propranolol.

摘要

在离体龟心中，牛甲状旁腺激素（b-PTH）（1-34）可刺激收缩力和心率（次/分钟），且对心率的刺激作用似乎更大。2. 异丙肾上腺素可刺激心率和收缩力，可能对收缩力的影响更大。3. 单独使用普萘洛尔可明显降低收缩力和心率。4. 用普萘洛尔预处理可消除bPTH（1-34）和异丙肾上腺素的刺激作用。普萘洛尔对异丙肾上腺素的作用在意料之中。其对bPTH（1-34）的作用可能与甲状旁腺激素的β刺激有关，或者与普萘洛尔的某些其他非特异性抑制作用有关。