Chevrel G, Page G, Miossec P
Department of Immunology and Rheumatology, Hôpital E. Herriot, Lyon, France.
Autoimmunity. 2006 May;39(3):171-6. doi: 10.1080/08916930600622173.
This review focuses on recent advances and new hypothesis in the understanding of the T and dendritic cells contribution to the pathogenesis of idiopathic inflammatory myopathies (IIMs), especially polymyositis (PM) and dermatomyositis (DM). The new data show that non-specific amplification of muscle inflammation by T lymphocyte and dendritic cells may result from the local production of cytokines and chemokines. Synergistic interactions between these factors explain some of the clinical features. The potent role of these molecules suggests their potential for therapeutic manipulation using specific inhibitors.
本综述聚焦于在理解T细胞和树突状细胞在特发性炎性肌病（IIM），尤其是多发性肌炎（PM）和皮肌炎（DM）发病机制中的作用方面的最新进展和新假说。新数据表明，T淋巴细胞和树突状细胞对肌肉炎症的非特异性放大可能源于细胞因子和趋化因子的局部产生。这些因素之间的协同相互作用解释了一些临床特征。这些分子的强大作用表明它们具有使用特异性抑制剂进行治疗性调控的潜力。
