Gardiner Katheleen, Du Yunzhi
Eleanor Roosevelt Institute at the University of Denver, 1899 Gaylord Street, Denver, CO 80206, USA.
Brief Funct Genomic Proteomic. 2006 Mar;5(1):37-42. doi: 10.1093/bfgp/ell006. Epub 2006 Feb 20.
Site-specific deamination of five adenosine residues in the pre-mRNA of the serotonin 2C receptor, 5HT2CR, alters the amino acid sequence of the encoded protein. Such RNA editing can produce 32 mRNA variants, encoding 24 protein isoforms that vary in biochemical and pharmacological properties. Because serotonin functions in the regulation of mood and behaviour, modulation of serotonin signalling by RNA editing may be relevant to such psychiatric disorders as anxiety and depression. Several recent human studies have reported changes in 5HT2CR editing in schizophrenia, major depression or suicide, but results are variable and not conclusive. Rodent studies have begun to examine effects of drug treatments and stress. Understanding the importance of 5HT2CR editing in mood and behaviour will be assisted by experiments designed to analyse multiple strains of mice, in different behavioural tests, with optimal evaluation of the time course of molecular changes.
血清素2C受体（5HT2CR）前体mRNA中五个腺苷残基的位点特异性脱氨基作用改变了所编码蛋白质的氨基酸序列。这种RNA编辑可产生32种mRNA变体，编码24种蛋白质异构体，它们在生化和药理学特性上有所不同。由于血清素在情绪和行为调节中发挥作用，RNA编辑对血清素信号的调节可能与焦虑和抑郁等精神疾病有关。最近的几项人体研究报告了精神分裂症、重度抑郁症或自杀患者中5HT2CR编辑的变化，但结果不一且尚无定论。啮齿动物研究已开始考察药物治疗和应激的影响。通过设计实验来分析不同行为测试中的多品系小鼠，并对分子变化的时间进程进行最佳评估，将有助于理解5HT2CR编辑在情绪和行为中的重要性。
