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迟发性心因性非癫痫性发作。

Late onset psychogenic nonepileptic attacks.

作者信息

Duncan Roderick, Oto Meritxell, Martin Emma, Pelosi Anthony

机构信息

West of Scotland Regional Epilepsy Service, Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland.

出版信息

Neurology. 2006 Jun 13;66(11):1644-7. doi: 10.1212/01.wnl.0000223320.94812.7a.

Abstract

OBJECTIVE

To investigate differences between groups of patients with early vs late onset psychogenic nonepileptic attacks (PNEA).

METHODS

The authors compared patients with onset of PNEA after age 55 years (n = 26) to patients whose onset of PNEA was before age 55 years (n = 241). The authors examined sociodemographic variables, factors potentially predisposing to PNEA, clinical semiology, and medical and psychiatric background.

RESULTS

Patients with late onset PNEA were more likely to be male (p = 0.029) (p values are quoted uncorrected for multiple comparisons). They were less likely to report antecedent sexual abuse (p = 0.008), and more likely to have severe physical health problems (p < 0.001) and to report health-related traumatic experiences (p < 0.0001). There were no clear differences in PNEA clinical semiology. There was a trend to better baseline mental health in the late onset group.

CONCLUSIONS

The data suggest a distinct subgroup of patients with late onset psychogenic nonepileptic attacks, in whom psychological trauma related to poor physical health plays a prominent role.

摘要

目的

研究早发性与晚发性心因性非癫痫性发作(PNEA)患者群体之间的差异。

方法

作者将55岁以后发病的PNEA患者(n = 26)与55岁以前发病的PNEA患者(n = 241)进行比较。作者研究了社会人口统计学变量、可能诱发PNEA的因素、临床症状学以及医学和精神科背景。

结果

晚发性PNEA患者更可能为男性(p = 0.029)(p值未针对多重比较进行校正)。他们报告有既往性虐待经历的可能性较小(p = 0.008),有严重身体健康问题的可能性较大(p < 0.001),报告与健康相关的创伤经历的可能性较大(p < 0.0001)。PNEA临床症状学方面无明显差异。晚发性组的基线心理健康状况有改善趋势。

结论

数据表明存在一个晚发性心因性非癫痫性发作的独特患者亚组,其中与身体健康不佳相关的心理创伤起主要作用。

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