Duncan Roderick, Oto Meritxell, Martin Emma, Pelosi Anthony
West of Scotland Regional Epilepsy Service, Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland.
Neurology. 2006 Jun 13;66(11):1644-7. doi: 10.1212/01.wnl.0000223320.94812.7a.
To investigate differences between groups of patients with early vs late onset psychogenic nonepileptic attacks (PNEA).
The authors compared patients with onset of PNEA after age 55 years (n = 26) to patients whose onset of PNEA was before age 55 years (n = 241). The authors examined sociodemographic variables, factors potentially predisposing to PNEA, clinical semiology, and medical and psychiatric background.
Patients with late onset PNEA were more likely to be male (p = 0.029) (p values are quoted uncorrected for multiple comparisons). They were less likely to report antecedent sexual abuse (p = 0.008), and more likely to have severe physical health problems (p < 0.001) and to report health-related traumatic experiences (p < 0.0001). There were no clear differences in PNEA clinical semiology. There was a trend to better baseline mental health in the late onset group.
The data suggest a distinct subgroup of patients with late onset psychogenic nonepileptic attacks, in whom psychological trauma related to poor physical health plays a prominent role.
研究早发性与晚发性心因性非癫痫性发作(PNEA)患者群体之间的差异。
作者将55岁以后发病的PNEA患者(n = 26)与55岁以前发病的PNEA患者(n = 241)进行比较。作者研究了社会人口统计学变量、可能诱发PNEA的因素、临床症状学以及医学和精神科背景。
晚发性PNEA患者更可能为男性(p = 0.029)(p值未针对多重比较进行校正)。他们报告有既往性虐待经历的可能性较小(p = 0.008),有严重身体健康问题的可能性较大(p < 0.001),报告与健康相关的创伤经历的可能性较大(p < 0.0001)。PNEA临床症状学方面无明显差异。晚发性组的基线心理健康状况有改善趋势。
数据表明存在一个晚发性心因性非癫痫性发作的独特患者亚组,其中与身体健康不佳相关的心理创伤起主要作用。