肌肉特异性激酶（MuSK）抗体阳性重症肌无力与HLA-DR14-DQ5密切相关。
Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5.
作者信息
Niks E H, Kuks J B M, Roep B O, Haasnoot G W, Verduijn W, Ballieux B E P B, De Baets M H, Vincent A, Verschuuren J J G M
机构信息
Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
出版信息
Neurology. 2006 Jun 13;66(11):1772-4. doi: 10.1212/01.wnl.0000218159.79769.5c.
The authors studied the HLA profile of 23 white Dutch patients with muscle-specific kinase antibody-positive myasthenia gravis (MuSK Ab+ MG) and found an association with HLA-DR14-DQ5 (odds ratio 8.5; 95% CI 3.9 to 18.7; p = 4.9 x 10(-5)). Fifty-two percent of the patients carried the DR14 allele compared with 5% of the controls (p = 1.0 x 10(-8)). This association between MuSK Ab+ MG and a relatively rare HLA haplotype differs from the previously described association of early-onset acetylcholine receptor Ab+ MG with HLA-B8-DR3.
作者研究了23例肌肉特异性激酶抗体阳性重症肌无力（MuSK Ab+ MG）的荷兰白人患者的HLA谱，发现其与HLA-DR14-DQ5相关（优势比8.5；95%可信区间3.9至18.7；p = 4.9×10⁻⁵）。52%的患者携带DR14等位基因，而对照组为5%（p = 1.0×10⁻⁸）。MuSK Ab+ MG与一种相对罕见的HLA单倍型之间的这种关联不同于先前描述的早发型乙酰胆碱受体抗体阳性重症肌无力与HLA-B8-DR3的关联。
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