Johnson Paul, Shore Angela, Potter John, Panerai Ronney, James Martin
Dept. of Medicine for the Elderly, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK.
Clin Auton Res. 2006 Aug;16(4):270-5. doi: 10.1007/s10286-006-0351-6. Epub 2006 Jun 12.
Baroreflex sensitivity (BRS) is impaired and of prognostic value in cerebrovascular disease. However, no studies to date have been published on the reproducibility of current methods of measuring BRS in this group. The reproducibility of sequence and spectral analysis methods were therefore assessed in subjects with cerebrovascular disease. A total of 14 subjects were assessed on 2 separate occasions at least 2 weeks apart, and beat-to-beat blood pressure (BP) and ECG trace were recorded for three 5-minute periods. These traces were then analyzed by spectral analysis using Fast Fourier Transform and sequence analysis. Reproducibility was calculated as the coefficient of variation (CV) and reproducibility coefficient (RC). There were no significant differences in heart rate, BP or BRS derived by either method between visits. Reproducibility was CV 22.2%, RC 6.04 ms/mmHg with spectral analysis, and CV 26.3%, RC 7.48 ms/mmHg for sequence analysis. There was close agreement between sequence and spectral derived BRS (r = 0.90). We have demonstrated that the use of spectral and sequence analysis to measure BRS is reproducible in subjects with cerebrovascular disease. These techniques are suitable for follow-up and intervention studies of BRS in this patient group.
压力反射敏感性（BRS）受损，且在脑血管疾病中具有预后价值。然而，迄今为止尚未发表关于该组中当前测量BRS方法的可重复性的研究。因此，对脑血管疾病患者评估了序列分析和频谱分析方法的可重复性。总共14名受试者在至少相隔2周的2个不同时间点接受评估，并在三个5分钟时间段记录逐搏血压（BP）和心电图。然后使用快速傅里叶变换通过频谱分析和序列分析对这些记录进行分析。可重复性计算为变异系数（CV）和可重复性系数（RC）。两次就诊之间，两种方法得出的心率、血压或BRS均无显著差异。频谱分析的可重复性为CV 22.2%，RC 6.04 ms/mmHg；序列分析的可重复性为CV 26.3%，RC 7.48 ms/mmHg。序列分析和频谱分析得出的BRS之间具有高度一致性（r = 0.90）。我们已经证明，在脑血管疾病患者中，使用频谱分析和序列分析测量BRS具有可重复性。这些技术适用于该患者组中BRS的随访和干预研究。
