Villamor Eduardo
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
Nutr Rev. 2006 May;64(5 Pt 1):226-33. doi: 10.1301/nr.2006.may.226-233.
Despite advances in the knowledge of vitamin D's potent immunomodulatory activity, its role on HIV disease progression is unknown. Decreased concentrations of 1alpha,25-hydroxyvitamin D3, or 1,25(OH)2D, the active form of vitamin D, have been reported among HIV-infected people and attributed to defects in renal hydroxylation and increased utilization. A few studies also described low levels of 25-hydroxyvitamin D3, 25(OH)D, the vitamin obtained from solar synthesis and diet. An inverse association between 1,25(OH)2D concentrations and mortality has been reported from a small cohort of HIV-infected adults, and some cross-sectional studies have indicated positive correlations between 1,25(OH)2D and CD4+ cell counts. Additional observational studies are needed to confirm the associations between vitamin D status and HIV disease progression. These investigations would provide useful insights on the potential role of vitamin D supplementation to HIV-infected persons and the planning of intervention trials.
尽管在维生素D强大的免疫调节活性方面的知识有所进展，但其在HIV疾病进展中的作用仍不清楚。据报道，在HIV感染者中，维生素D的活性形式1α,25-二羟维生素D3（1,25(OH)2D）浓度降低，这归因于肾脏羟化缺陷和利用率增加。一些研究还描述了从阳光合成和饮食中获得的维生素25-羟维生素D3（25(OH)D）水平较低。在一小群HIV感染成年人中，已报道1,25(OH)2D浓度与死亡率呈负相关，一些横断面研究表明1,25(OH)2D与CD4+细胞计数呈正相关。需要更多的观察性研究来证实维生素D状态与HIV疾病进展之间的关联。这些调查将为维生素D补充剂对HIV感染者的潜在作用以及干预试验的规划提供有用的见解。
