Rusavý Z, Lacigová S, Jankovec Z, Zourek M, Krcma M
Diabetologické a nutricní centrum, I. interní klinika Lékarské fakulty UK a FN, Plzen.
Vnitr Lek. 2006 May;52(5):429-32; discussion 433.
The study surveys potential effects of hyperglycemia on prognosis, complications and mortality of critical patients. Normalization of glycemia seems to be an effective therapeutic approach that influences morbidity and mortality of critical patients. Although insulin therapy has many positive effects, it is rather a way how to achieve normoglycemia. Authors present their own research of the impact of plasmatic insulin levels on glucose metabolism. It seems that the ability of critical patients to utilise and store glucose is significantly decreased due to their insulin resistance. Glucose oxidation is decreased only slightly. Glucose utilisation and oxidation in sepsis can be enhanced by administration of insulin.
该研究调查了高血糖对危重症患者预后、并发症和死亡率的潜在影响。血糖正常化似乎是一种影响危重症患者发病率和死亡率的有效治疗方法。尽管胰岛素治疗有许多积极作用，但它只是实现血糖正常的一种方式。作者展示了他们自己关于血浆胰岛素水平对葡萄糖代谢影响的研究。由于危重症患者存在胰岛素抵抗，他们利用和储存葡萄糖的能力似乎显著下降。葡萄糖氧化仅略有下降。脓毒症时给予胰岛素可增强葡萄糖的利用和氧化。
