Vijayaraghavan Rajagopalan, Chandrashekar Rangashamaiah, Melkote Jyotiprakash Avinash, Kumar Ravi, Rashmi M V, Shanmukhappa Belagavi Charalingappa
Departments of Surgery, RMV Hospital, No. 138, AECS Layout, Sanjaynagar, Bangalore 560094, India.
Eur J Gastroenterol Hepatol. 2006 Jul;18(7):773-6.
Intestinal neuronal dysplasia (IND) is a well-documented but controversial entity defined as a congenital malformation of gastrointestinal innervation caused by dysplastic embryonal development of the enteric nervous system. Mainly described as a colonic disorder mimicking Hirschsprung's disease in the paediatric population, involvement of the ileum is rare. We report a case of fatal IND of the small intestine in a 58-year-old man presenting with a recent onset of features of small intestinal obstruction. IND has been described as a cause of colonic pseudo-obstruction and chronic constipation in adults, but to the best of our knowledge, this is the first report of IND of the ileum occurring in an adult causing fatal small bowel obstruction. A Medline search yielded no cases of ileal involvement with IND in adults.
肠道神经元发育异常（IND）是一种有充分文献记载但存在争议的病症，定义为因肠神经系统发育异常的胚胎发育导致的胃肠道神经支配先天性畸形。主要被描述为儿科人群中一种类似先天性巨结肠的结肠疾病，累及回肠的情况罕见。我们报告一例58岁男性小肠致命性IND病例，该患者近期出现小肠梗阻症状。IND已被描述为成人结肠假性梗阻和慢性便秘的一个病因，但据我们所知，这是首例成人回肠IND导致致命性小肠梗阻的报告。医学文献检索未发现成人IND累及回肠的病例。
