Géant Elodie, Mouchel-Vielh Emmanuèle, Coutanceau Jean-Pierre, Ozouf-Costaz Catherine, Deutsch Jean S
Développement et Evolution, UMR 7622, CNRS et Université P. et M. Curie, case 24, 9 quai St-Bernard, 75252 Paris cedex 05, France.
Dev Genes Evol. 2006 Jul-Aug;216(7-8):443-9. doi: 10.1007/s00427-006-0088-1. Epub 2006 Jun 14.
The "hopeful monster" has haunted evolutionary thinking since Richard Goldschmidt coined the phrase in 1933. The phrase is directly related to genetic mechanisms in development and evolution. Cirripedes are peculiar crustaceans in that they all lack abdomens as adults. In a previous study aimed at describing the repertoire of Hox genes of the Cirripedia, we failed to isolate the abdominal-A gene in three species representative of all three cirripede orders. To address the question of whether the cirripede ancestor could have been a "hopeful monster" arising from a rearrangement of the Hox complex, we have performed a cytogenetic analysis of the Hox complex of the cirripede Sacculina carcini. We present here molecular and cytogenetic evidence for the grouping of the Hox genes on a single chromosome. This is the first direct evidence reported for the grouping of Hox genes on the same chromosome in a non-insect arthropod species.
自1933年理查德·戈德施密特创造“有希望的怪物”这一术语以来，它一直困扰着进化思想。该术语与发育和进化中的遗传机制直接相关。蔓足类是独特的甲壳类动物，因为它们成年后都没有腹部。在先前一项旨在描述蔓足类动物Hox基因库的研究中，我们未能在代表蔓足类所有三个目的三个物种中分离出腹部-A基因。为了解决蔓足类祖先是否可能是由Hox复合体重排产生的“有希望的怪物”这一问题，我们对蔓足类蟹奴的Hox复合体进行了细胞遗传学分析。我们在此展示了Hox基因在一条染色体上成簇的分子和细胞遗传学证据。这是首次报道非昆虫节肢动物物种中Hox基因在同一条染色体上成簇的直接证据。
