Rzepka-Górska Izabella, Tarnowski Bogusław, Chudecka-Głaz Anita, Górski Bohdan, Zielińska Dorota, Tołoczko-Grabarek Aleksandra
Department of Gynecological Surgery and Oncology of Adults and Adolescents, Pomeranian Medical University of Szczecin, Poland, ul. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Breast Cancer Res Treat. 2006 Nov;100(1):59-63. doi: 10.1007/s10549-006-9220-1. Epub 2006 Jun 14.
This study was undertaken with regard to the gonadotropin theory of ovarian cancer advocated in the literature and was designed to disclose specific features of ovarian morphology in carriers of the BRCA1 gene mutation. We enrolled 171 patients and divided them into two groups: A (n=90)--operated for breast cancer (30 patients with and 60 without the BRCA1 mutation); B (n=81)--with the BRCA1 mutation qualified for preventive adnexectomy. According to the authors' classification described herein, some patients without the BRCA1 mutation retained "signs of estrogenization" in menopausal ovaries, revealing the role of estrogens as a factor promoting mammary carcinogenesis in these patients. A tendency to premature menopause was observed in BRCA1 mutation carriers of groups A and B as evidenced by the final menorrhea appearing at a younger age and almost total absence of "signs of estrogenization" in menopausal ovaries. It is concluded from these findings that earlier menopause in carriers of the BRCA1 mutation is associated with hypergonadotropic activity and may predispose to ovarian cancer at younger age.
本研究是针对文献中提出的卵巢癌促性腺激素理论进行的，旨在揭示携带BRCA1基因突变者卵巢形态的具体特征。我们招募了171名患者，并将他们分为两组：A组（n = 90）——接受乳腺癌手术（30例携带BRCA1基因突变，60例未携带）；B组（n = 81）——携带BRCA1基因突变且符合预防性附件切除术条件。根据本文所述的作者分类，一些未携带BRCA1基因突变的患者在绝经后卵巢中保留了“雌激素化迹象”，揭示了雌激素在这些患者中作为促进乳腺癌发生因素的作用。A组和B组的BRCA1基因突变携带者均出现了过早绝经的趋势，表现为末次月经年龄较小，且绝经后卵巢中几乎完全没有“雌激素化迹象”。从这些发现可以得出结论，BRCA1基因突变携带者较早绝经与高促性腺激素活性有关，可能使她们在年轻时易患卵巢癌。
