[滑膜液中转化生长因子-β对免疫活性细胞的调节作用]
[Modulation of immunocompetent cells in the synovial fluid TGF-beta].
作者信息
Kekow J, Gross W L, Carson D A, Lotz M
机构信息
Medizinische Abteilung der Rheumaklinik Bad Bramstedt.
出版信息
Immun Infekt. 1991 Apr;19(2):60-1.
PMID:1677345
Abstract
Mononuclear cells (MNC) in synovial fluids from patients with rheumatoid arthritis and other arthropathies differ clearly from MNC in peripheral blood. Typically the ratio of CD4(+)-/CD8+ lymphocytes is inverted and the response to mitogens/cytokines (IL-1/IL-2) is impaired. Active TGF-beta (transforming growth factor beta) was found to account for these abnormalities, and the major isoform was identified as TGF-beta 2.
摘要
类风湿性关节炎和其他关节病患者滑液中的单核细胞（MNC）与外周血中的单核细胞明显不同。通常，CD4(+)/CD8+淋巴细胞的比例倒置，对丝裂原/细胞因子（IL-1/IL-2）的反应受损。研究发现，活性转化生长因子β（TGF-β）是导致这些异常的原因，其主要异构体被鉴定为TGF-β2。
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