Lin J S, Lin C K, Liu S M, Chen L Y, Wang S Y
Department of Medicine, Veterans General Hospital-Taipei, Taiwan, R.O.C.
J Formos Med Assoc. 1991 Mar;90(3):232-9.
Forty-three patients with myelodysplastic syndrome (MDS) were retrospectively analyzed for its prognostic factors. We evaluated the relationship of the clinical, biochemical, and hematological data, as well as colony-forming unit myeloid (CFU-C) culture, Bournemouth score, modified Bournemouth score, and modified Dutcher score to the prognosis. The median age was 65 years. Eighteen patients had refractory anemia (RA), 4 had refractory anemia with ringed sideroblasts (RARS), 15 had refractory anemia with excess blasts (RAEB), 2 had refractory anemia with excess blasts in transformation (RAEB-t), and 4 had chronic myelomonocytic leukemia (CMMoL). The median survival of all patients was 482 days. The median survival for each subtype was as follows: RA, 628 days; CMMoL, 350 days; RAEB, 240 days; RAEB-t, 90 days. For RARS, no data have yet been obtained, because only one out of 4 patients with RARS has died. We subdivided all patients into two groups: one group included patients with RA or RARS and the other group included patients with RAEB, RAEB-t or CMMoL. The former group had a median survival of 677 days and the latter group 240 days, p = 0.0035. In the former group, 3 out of 22 patients (13.6%) developed acute myeloid leukemia (AML), as compared to 8 out of 21 patients (38.1%) in the latter group, p = 0.0661. Twenty-five of the 43 patients died: 10 from AML and 15 from infection and/or bleeding.(ABSTRACT TRUNCATED AT 250 WORDS)
对43例骨髓增生异常综合征（MDS）患者的预后因素进行回顾性分析。我们评估了临床、生化和血液学数据，以及髓系集落形成单位（CFU-C）培养、伯恩茅斯评分、改良伯恩茅斯评分和改良达彻评分与预后的关系。中位年龄为65岁。18例患者为难治性贫血（RA），4例为环形铁粒幼细胞难治性贫血（RARS），15例为原始细胞过多难治性贫血（RAEB），2例为转化中的原始细胞过多难治性贫血（RAEB-t），4例为慢性粒-单核细胞白血病（CMMoL）。所有患者的中位生存期为482天。各亚型的中位生存期如下：RA为628天；CMMoL为350天；RAEB为240天；RAEB-t为90天。对于RARS，尚未获得数据，因为4例RARS患者中只有1例死亡。我们将所有患者分为两组：一组包括RA或RARS患者，另一组包括RAEB、RAEB-t或CMMoL患者。前一组的中位生存期为677天，后一组为240天，p = 0.0035。在前一组中，22例患者中有3例（13.6%）发展为急性髓系白血病（AML），而后一组21例患者中有8例（38.1%），p = 0.0661。43例患者中有25例死亡：10例死于AML，15例死于感染和/或出血。（摘要截断于250字）
