Crowe S M, Carlin J B, Stewart K I, Lucas C R, Hoy J F
Macfarlane Burnet Centre for Medical Research, Fairfield Hospital, Melbourne, Australia.
J Acquir Immune Defic Syndr (1988). 1991;4(8):770-6.
Infection with the human immunodeficiency virus (HIV) results in progressive depletion of the CD4 subset T-lymphocytes and the development of opportunistic infections and certain malignancies. Charts were reviewed for 185 HIV-infected individuals with 265 AIDS-defining illnesses (ADIs) who had T-lymphocyte subset analyses performed within 2 months prior to or 1 month following the diagnosis. Also included were 22 HIV-infected patients with oral candidiasis and 20 with asymptomatic infection. Significant differences in CD4 lymphocyte numbers were observed between the 12 ADIs, oral candidiasis, and asymptomatic infection, allowing them to be grouped into five general categories, based on mean CD4 count: (a) asymptomatic infection, CD4 greater than 500/mm3; (b) oral candidiasis and tuberculosis, range 250-500/mm3; (c) Kaposi's sarcoma, lymphoma, and cryptosporidiosis, range 150-200/mm3; (d) Pneumocystis carinii pneumonitis, disseminated Mycobacterium avium complex, herpes simplex ulceration, toxoplasmosis, cryptococcosis, and esophageal candidiasis, range 75-125/mm3; (e) cytomegalovirus retinitis, less than 50/mm3. Our data concur with clinical impressions and provide a basis for interim treatment and prophylaxis recommendations.
感染人类免疫缺陷病毒（HIV）会导致CD4亚群T淋巴细胞逐渐耗竭，并引发机会性感染和某些恶性肿瘤。对185例感染HIV且患有265种艾滋病定义疾病（ADI）的个体病历进行了回顾，这些个体在诊断前2个月内或诊断后1个月内进行了T淋巴细胞亚群分析。还纳入了22例患有口腔念珠菌病的HIV感染患者和20例无症状感染患者。在12种ADI、口腔念珠菌病和无症状感染之间观察到CD4淋巴细胞数量存在显著差异，根据平均CD4计数可将它们分为五大类：（a）无症状感染，CD4大于500/mm³；（b）口腔念珠菌病和结核病，范围为250 - 500/mm³；（c）卡波西肉瘤、淋巴瘤和隐孢子虫病，范围为150 - 200/mm³；（d）卡氏肺孢子虫肺炎、播散性鸟分枝杆菌复合体、单纯疱疹溃疡、弓形虫病、隐球菌病和食管念珠菌病，范围为75 - 125/mm³；（e）巨细胞病毒性视网膜炎，小于50/mm³。我们的数据与临床印象相符，并为临时治疗和预防建议提供了依据。
