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本文引用的文献

1
Chemical synthesis and molecular recognition of phosphatase-resistant analogues of phosphatidylinositol-3-phosphate.磷脂酰肌醇-3-磷酸的磷酸酶抗性类似物的化学合成与分子识别
J Am Chem Soc. 2006 Jan 25;128(3):885-97. doi: 10.1021/ja0554716.
2
Acyclic nucleoside phosphonates: a key class of antiviral drugs.无环核苷膦酸酯：一类关键的抗病毒药物。
Nat Rev Drug Discov. 2005 Nov;4(11):928-40. doi: 10.1038/nrd1877.
3
Targeting of the FYVE domain to endosomal membranes is regulated by a histidine switch.FYVE结构域定位于内体膜是由一个组氨酸开关调控的。
Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13052-7. doi: 10.1073/pnas.0503900102. Epub 2005 Sep 2.
4
Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors.
Farmaco. 2004 Nov;59(11):887-92. doi: 10.1016/j.farmac.2004.08.002.
5
Phosphoinositide signaling; from affinity probes to pharmaceutical targets.磷酸肌醇信号传导：从亲和探针到药物靶点。
Chem Biol. 2004 May;11(5):619-37. doi: 10.1016/j.chembiol.2004.03.025.
6
PI3P signaling regulates receptor sorting but not transport in the endosomal pathway.磷脂酰肌醇3-磷酸（PI3P）信号传导调节受体分选，但不调节内体途径中的转运。
J Cell Biol. 2003 Sep 15;162(6):971-9. doi: 10.1083/jcb.200303018.
7
Myotubularins, a large disease-associated family of cooperating catalytically active and inactive phosphoinositides phosphatases.肌管素，是一个与疾病相关的大家族，由具有催化活性和无催化活性的磷酸肌醇磷酸酶协同组成。
Hum Mol Genet. 2003 Oct 15;12 Spec No 2:R285-92. doi: 10.1093/hmg/ddg273. Epub 2003 Aug 12.
8
Class I phosphoinositide 3-kinases.I类磷酸肌醇3-激酶
Int J Biochem Cell Biol. 2003 Jul;35(7):1028-33. doi: 10.1016/s1357-2725(02)00270-4.
9
Comprehensive and uniform synthesis of all naturally occurring phosphorylated phosphatidylinositols.所有天然存在的磷酸化磷脂酰肌醇的全面且统一的合成。
J Org Chem. 2003 Feb 7;68(3):960-8. doi: 10.1021/jo0206418.
10
Phosphoinositide 3-kinase gamma: a key modulator in inflammation and allergy.磷脂酰肌醇3-激酶γ：炎症和过敏中的关键调节因子。
Biochem Soc Trans. 2003 Feb;31(Pt 1):275-80. doi: 10.1042/bst0310275.

磷脂酰肌醇-3-亚甲基磷酸酯的合成与分子识别

Synthesis and molecular recognition of phosphatidylinositol-3-methylenephosphate.

作者信息

Gajewiak Joanna, Xu Yong, Lee Stephanie A, Kutateladze Tatiana G, Prestwich Glenn D

机构信息

Department of Medicinal Chemistry, The University of Utah, Salt Lake City, 84108-1257, USA.

出版信息

Org Lett. 2006 Jun 22;8(13):2811-3. doi: 10.1021/ol060903i.

DOI:10.1021/ol060903i
PMID:16774263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2535797/
Abstract

[reaction: see text] Phosphatidylinositol-3-phosphate (PtdIns(3)P) is a spatial regulator of vesicular trafficking and other vital cellular processes. We describe the asymmetric total synthesis of a metabolically stabilized analogue, phosphatidylinositol-3-methylenephosphate (PtdIns(3)MP) from a differentially protected myo-inositol. NMR studies of PtdIns(3)MP bound to the (15)N-labeled FYVE domain showed significant (1)H and (15)N chemical shift changes relative to the unliganded protein.

摘要

[反应：见正文] 磷脂酰肌醇-3-磷酸（PtdIns(3)P）是囊泡运输及其他重要细胞过程的空间调节因子。我们描述了一种代谢稳定类似物磷脂酰肌醇-3-亚甲基磷酸（PtdIns(3)MP）从差异保护的肌醇的不对称全合成。对与(15)N标记的FYVE结构域结合的PtdIns(3)MP的核磁共振研究表明，相对于未结合配体的蛋白质，其(1)H和(15)N化学位移有显著变化。