Fecho K, Valtschanoff J G
Department of Anesthesiology, Division of Pain Medicine, The University of North Carolina at Chapel Hill, NC 27599-7010, USA.
J Neuroendocrinol. 2006 Jul;18(7):504-13. doi: 10.1111/j.1365-2826.2006.01442.x.
Inbred, histocompatible Lewis and Fischer 344 rats (LEW and FIS) have been used to identify an inverse relationship between hypothalamic-pituitary-adrenal (HPA) axis activity and susceptibility to autoimmune and chronic inflammatory disorders, with LEW showing blunted HPA axis activity and increased susceptibility toward the development of autoimmunity and chronic inflammation, and FIS showing the opposite relationship. In the present study, LEW and FIS were used to determine the relationship between HPA axis function and acute inflammatory pain (carrageenan-induced hindpaw inflammation) and neuropathic pain (partial sciatic nerve ligation; PSNL). The results showed that carrageenan-induced thermal and mechanical allodynia and hyperalgesia were greater in FIS than in LEW. Similarly, FIS showed more carrageenan-induced hindpaw swelling and higher levels of myeloperoxidase (a measure of neutrophils) in the carrageenan-inflamed hindpaw. After PSNL, LEW showed a profound mechanical allodynia and hyperalgesia, whereas mechanical sensitivity in FIS was unaltered. However, FIS, but not LEW, developed thermal allodynia and hyperalgesia after PSNL. These results provide strong evidence for a positive relationship between HPA axis activity and acute inflammatory pain. The results also support a relationship between HPA axis activity and neuropathic pain, but the relationship is complex and may depend on the pain assay.
近交、组织相容性的刘易斯大鼠和费希尔344大鼠（LEW和FIS）已被用于确定下丘脑-垂体-肾上腺（HPA）轴活性与自身免疫性和慢性炎症性疾病易感性之间的负相关关系，LEW表现出HPA轴活性减弱，对自身免疫和慢性炎症发展的易感性增加，而FIS表现出相反的关系。在本研究中，LEW和FIS被用于确定HPA轴功能与急性炎性疼痛（角叉菜胶诱导的后爪炎症）和神经性疼痛（坐骨神经部分结扎；PSNL）之间的关系。结果表明，角叉菜胶诱导的热和机械性痛觉过敏及痛觉超敏在FIS中比在LEW中更明显。同样，FIS在角叉菜胶诱导的后爪炎症中表现出更多的后爪肿胀和更高水平的髓过氧化物酶（中性粒细胞的一种测量指标）。PSNL后，LEW表现出严重的机械性痛觉过敏和痛觉超敏，而FIS中的机械敏感性未改变。然而，PSNL后FIS出现了热痛觉过敏和痛觉超敏，而LEW没有。这些结果为HPA轴活性与急性炎性疼痛之间的正相关关系提供了有力证据。结果还支持HPA轴活性与神经性疼痛之间的关系，但这种关系很复杂，可能取决于疼痛检测方法。
