Nesvåg R, Hendset M, Refsum H, Tanum L
Psychiatric Research, Djakonhjemmet Hospital, Oslo, Norway.
Acta Psychiatr Scand. 2006 Jul;114(1):21-6. doi: 10.1111/j.1600-0447.2006.00840.x.
To compare serum concentrations of risperidone, 9-hydroxy (OH) risperidone and risperidone plus 9-OH risperidone, as well as the 9-OH risperidone/risperidone ratio in patients receiving depot and oral risperidone.
Serum concentrations from 78 patients receiving three different doses of risperidone depot were measured and compared with serum concentrations from 82 patients taking three different doses of oral risperidone.
Patients receiving risperidone depot had significantly lower serum concentrations of risperidone plus 9-OH risperidone than patients taking oral risperidone. More interestingly, the 9-OH risperidone/risperidone ratio was also significantly lower in patients receiving risperidone depot than in patients taking oral risperidone.
Serum concentrations of risperidone plus 9-OH risperidone may be a rather poor indication of the antipsychotic efficacy of risperidone unless their ratio is also considered.
比较接受长效利培酮和口服利培酮治疗的患者血清中利培酮、9-羟基（OH）利培酮、利培酮加9-OH利培酮的浓度，以及9-OH利培酮/利培酮的比值。
测量78例接受三种不同剂量长效利培酮治疗患者的血清浓度，并与82例服用三种不同剂量口服利培酮患者的血清浓度进行比较。
接受长效利培酮治疗的患者血清中利培酮加9-OH利培酮的浓度显著低于口服利培酮的患者。更有趣的是，接受长效利培酮治疗的患者9-OH利培酮/利培酮的比值也显著低于口服利培酮的患者。
除非同时考虑利培酮加9-OH利培酮的比值，否则其血清浓度可能不能很好地反映利培酮的抗精神病疗效。
