Bernatowska Ewa, Mikołuć Bozena, Krzeski Antoni, Piatosa Barbara, Gromek Iwona
Department of Immunology, The Children's Memorial Health Institute, Av. Dzieci Polskich 20, 04-736 Warsaw, Poland.
Int J Pediatr Otorhinolaryngol. 2006 Sep;70(9):1587-92. doi: 10.1016/j.ijporl.2006.04.013. Epub 2006 Jun 13.
Some patients suffer from recurrent or chronic rhinosinusitis (CRS) because of previously unrecognized immunodeficiency disease. The purpose of the study was to evaluate the incidence of CRS in children with different types of primary humoral deficiency.
Among 842 cases of primary immunodeficiency diseases diagnosed in the Department of Immunology of the Children's Memorial Institute in Warsaw from 1980 up to February 2006 antibody deficiencies occurred most frequently--in 50.4%. In this group the retrospective study of patients' history suggesting CRS prior to intravenous gamma-globulin substitution therapy was performed.
CRS was observed most frequently in the group of patients with agammaglobulinemia less often in patients with dysgammaglobulinemia, and other antibody deficiencies.
The occurrence of frequent bacterial infections, complicating common colds, should alert the physician to the possibility of immunodeficiency. Immunological testing should be an integral part of evaluation of patients with refractory CRS.
一些患者因先前未被识别的免疫缺陷疾病而患有复发性或慢性鼻-鼻窦炎（CRS）。本研究的目的是评估不同类型原发性体液免疫缺陷儿童中CRS的发病率。
1980年至2006年2月期间，在华沙儿童纪念研究所免疫科诊断的842例原发性免疫缺陷疾病中，抗体缺陷最为常见，占50.4%。在该组中，对患者病史进行回顾性研究，以了解静脉注射丙种球蛋白替代治疗前提示CRS的情况。
CRS在无丙种球蛋白血症患者组中最常见，在丙种球蛋白异常血症患者及其他抗体缺陷患者中较少见。
频繁的细菌感染伴发普通感冒，应提醒医生注意免疫缺陷的可能性。免疫检测应作为难治性CRS患者评估的一个组成部分。
