Jokubkiene Ligita, Sladkevicius Povilas, Rovas Linas, Valentin Lil
Obstetric, Gynecological and Prenatal Ultrasound Research Unit, Department of Clinical Sciences, Lund University and Department of Obstetrics and Gynecology, Malmö University Hospital, Malmö, Sweden.
Hum Reprod. 2006 Oct;21(10):2661-8. doi: 10.1093/humrep/del211. Epub 2006 Jun 14.
Our aim was to describe changes in the volume and vascularization of both ovaries, the dominant follicle and the corpus luteum during the normal menstrual cycle using three-dimensional (3D) power Doppler ultrasound.
Fourteen healthy volunteers underwent serial transvaginal 3D ultrasound examinations of both ovaries on cycle day 2, 3 or 4, then daily from cycle day 9 until follicular rupture and 1, 2, 5, 7 and 12 days after follicular rupture. The volume and vascular indices of the ovaries, the dominant follicle and the corpus luteum were calculated off-line using virtual organ computer-aided analysis (VOCAL) software.
The volume of the dominant ovary increased during the follicular phase, decreased after follicular rupture and then increased again during the luteal phase. Vascular indices in the dominant ovary and the dominant follicle/corpus luteum increased during the follicular phase, the vascular flow index (VFI) in the dominant follicle being on average (median) 1.7 times higher on the day before ovulation than 4 days before ovulation (P=0.003). The vascular indices continued to rise after follicular rupture so that VFI in the corpus luteum was on average (median) 3.1 times higher 7 days after ovulation than in the follicle on the day before ovulation (P=0.0002). The volume and vascular indices in the non-dominant ovary manifested no unequivocal changes during the menstrual cycle.
Substantial changes occur in volume and vascularization of the dominant ovary during the normal menstrual cycle. 3D power Doppler ultrasound may become a useful tool for assessing pathological changes in the ovaries, for example, in subfertile patients.
我们的目的是使用三维（3D）能量多普勒超声描述正常月经周期中双侧卵巢、优势卵泡和黄体的体积及血管形成的变化。
14名健康志愿者在月经周期第2、3或4天接受双侧卵巢的系列经阴道3D超声检查，然后从周期第9天开始每日检查，直至卵泡破裂，并在卵泡破裂后1、2、5、7和12天进行检查。使用虚拟器官计算机辅助分析（VOCAL）软件离线计算卵巢、优势卵泡和黄体的体积及血管指数。
优势卵巢的体积在卵泡期增加，卵泡破裂后减小，然后在黄体期再次增加。优势卵巢以及优势卵泡/黄体的血管指数在卵泡期增加，优势卵泡的血管血流指数（VFI）在排卵前一天平均（中位数）比排卵前4天高1.7倍（P = 0.003）。卵泡破裂后血管指数持续上升，以至于黄体的VFI在排卵后7天平均（中位数）比排卵前一天卵泡中的VFI高3.1倍（P = 0.0002）。非优势卵巢的体积和血管指数在月经周期中未表现出明确变化。
在正常月经周期中，优势卵巢的体积和血管形成发生显著变化。3D能量多普勒超声可能成为评估卵巢病理变化（例如在不育患者中）的有用工具。
