Vajdic Claire M, Grulich Andrew E, Kaldor John M, Fritschi Lin, Benke Geza, Hughes Ann Maree, Kricker Anne, Turner Jennifer J, Milliken Sam, Armstrong Bruce K
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Level 2/376 Victoria Street, Darlinghurst, New South Wales 2010, Australia.
Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1102-8. doi: 10.1158/1055-9965.EPI-06-0078.
Infections were examined as possible risk factors for non-Hodgkin lymphoma in a population-based case-control study in New South Wales and the Australian Capital Territory, Australia. Incident cases (n = 694) had no history of HIV infection or transplantation. Controls (n = 694) were randomly selected from electoral rolls and frequency matched to cases by age, sex, and area of residence. A postal questionnaire and telephone interview measured history of specific infections, occupational exposures, and behavioral and other risk factors for infection. Blood samples were tested for antibodies to human T-lymphotrophic virus type I and hepatitis C virus. Logistic regression models included the three matching variables and ethnicity. There was no association between risk of non-Hodgkin lymphoma and any of the variables analyzed, including sexually transmitted infections, sexual behavior, blood transfusions, influenza, acne, and either occupational or domestic exposure to zoonotic infections. Non-Hodgkin lymphoma risk was nonsignificantly elevated (odds ratio, 2.99; 95% confidence interval, 0.78-11.51) for those with a history of injecting drug use. Three cases and two controls (odds ratio, 1.32; 95% confidence interval, 0.22-7.98) tested positive to hepatitis C virus infection and none tested positive to human T-lymphotrophic virus type I/II infection. This study provides consistent evidence that sexually transmitted infections and zoonoses are not risk factors for non-Hodgkin lymphoma.
在澳大利亚新南威尔士州和澳大利亚首都直辖区开展的一项基于人群的病例对照研究中，对感染作为非霍奇金淋巴瘤可能的风险因素进行了调查。确诊病例（n = 694）无艾滋病毒感染或移植史。对照（n = 694）从选民名单中随机选取，并按年龄、性别和居住地区与病例进行频数匹配。通过邮政问卷和电话访谈来衡量特定感染史、职业暴露以及感染的行为和其他风险因素。对血样进行了抗I型人类嗜T淋巴细胞病毒和丙型肝炎病毒抗体检测。逻辑回归模型纳入了三个匹配变量和种族。非霍奇金淋巴瘤风险与所分析的任何变量之间均无关联，这些变量包括性传播感染、性行为、输血、流感、痤疮以及职业或家庭接触人畜共患感染。有注射吸毒史者的非霍奇金淋巴瘤风险虽有升高但无统计学意义（比值比，2.99；95%置信区间，0.78 - 11.51）。3例病例和2例对照（比值比，1.32；95%置信区间，0.22 - 7.98）丙型肝炎病毒感染检测呈阳性，无一例I/II型人类嗜T淋巴细胞病毒感染检测呈阳性。本研究提供了一致的证据，表明性传播感染和人畜共患病并非非霍奇金淋巴瘤的风险因素。
