de Villiers Ethel-Michele, Zur Hausen Harald
Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Cancers (Basel). 2021 Oct 28;13(21):5407. doi: 10.3390/cancers13215407.
Exemplified by infections with bovine meat and milk factors (BMMFs), this manuscript emphasizes the different mechanistic aspects of infectious agents contributing to human cancers by "direct" or "indirect" interactions. The epidemiology of cancers linked to direct carcinogens (e.g., response to immunosuppression) differs from those cancers linked with indirect infectious interactions. Cancers induced by direct infectious carcinogens commonly increase under immunosuppression, whereas the cancer risk by indirect carcinogens is reduced. This influences their responses to preventive and therapeutic interferences. In addition, we discuss their role in colon, breast and prostate cancers and type II diabetes mellitus. A brief discussion covers the potential role of BMMF infections in acute myeloid leukemia.
以牛源肉和奶因子(BMMFs)感染为例,本手稿强调了感染因子通过“直接”或“间接”相互作用导致人类癌症的不同机制方面。与直接致癌物相关的癌症流行病学(例如对免疫抑制的反应)与那些与间接感染相互作用相关的癌症不同。由直接感染性致癌物诱发的癌症在免疫抑制下通常会增加,而间接致癌物导致的癌症风险则会降低。这影响了它们对预防和治疗干预的反应。此外,我们还讨论了它们在结肠癌、乳腺癌和前列腺癌以及II型糖尿病中的作用。简短讨论涵盖了BMMF感染在急性髓系白血病中的潜在作用。