Valencia R, Stuermer E K, Dullin C, Herrmann K P, Kluever I, Zaroban A, Sehmisch S, Funke M, Knollmann F
Abteilung Diagnostische Radiologie, Universitätsklinikum Göttingen.
Radiologe. 2006 Oct;46(10):893-9. doi: 10.1007/s00117-006-1390-7.
Flat-panel volumetric computed tomography (fpVCT) is a new, noninvasive CT imaging modality with increased isotropic resolution. Technical details, potential applications, and our initial experience with a fpVCT prototype scanner in the imaging of osteoporosis in a rat model are presented.
To date, 21 rats have been investigated in vivo with fpVCT. Pharmacologic effects on bone mineral density (BMD) and structure were of special interest. Image evaluation focussed on the second lumbar vertebra and the left femoral bone. To validate measurement results, BMD values calculated with fpVCT were correlated with results of BMD measurements from ashing of the second lumbar vertebra and femoral bones.
Our initial results show that fpVCT is capable of detecting differences in BMD between ovariectomized rats treated with estradiol and a control group with high statistical significance (p<0.05), corresponding to ashing as the gold standard.
In a rat model, fpVCT imaging is especially useful in longitudinal in vivo investigations of BMD measures. Spatial resolution of up to 150 microm allows imaging of the trabecular structure only in human cadaveric bones.
平板容积计算机断层扫描（fpVCT）是一种新型的无创CT成像模式，具有更高的各向同性分辨率。本文介绍了其技术细节、潜在应用以及我们使用fpVCT原型扫描仪对大鼠骨质疏松症成像的初步经验。
迄今为止，已对21只大鼠进行了fpVCT活体研究。特别关注对骨矿物质密度（BMD）和骨结构的药理作用。图像评估集中在第二腰椎和左股骨。为验证测量结果，将fpVCT计算的BMD值与第二腰椎和股骨灰化后的BMD测量结果进行相关性分析。
我们的初步结果表明，fpVCT能够检测出用雌二醇治疗的去卵巢大鼠与对照组之间的BMD差异，具有高度统计学意义（p<0.05），与作为金标准的灰化法相当。
在大鼠模型中，fpVCT成像在BMD测量的纵向活体研究中特别有用。高达150微米的空间分辨率仅能对人类尸体骨骼的小梁结构进行成像。
