Mani Neelakandha S, Mapes Christopher M, Wu Jiejun, Deng Xiaohu, Jones Todd K
Department of Drug Discovery, Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 3210 Merryfield Row, San Diego, California 92121, USA.
J Org Chem. 2006 Jun 23;71(13):5039-42. doi: 10.1021/jo060586t.
An efficient method for the stereoselective synthesis of (Z)-alpha-arylacrylates is described. Treatment of alpha-hydroxyesters with triflic anhydride and pyridine at 0 degrees C followed by warming to room temperature afforded the corresponding (Z)-alpha-aryl-alpha,beta-unsaturated esters in very good yields and excellent stereoselectivity.
描述了一种立体选择性合成(Z)-α-芳基丙烯酸酯的有效方法。α-羟基酯在0℃下用三氟甲磺酸酐和吡啶处理，然后升温至室温，以非常高的产率和优异的立体选择性得到相应的(Z)-α-芳基-α,β-不饱和酯。
